Chemotherapy of acute leukemia. Comparison of cytarabine alone and in combination with vincristine, prednisone, and cyclophosphamide.
Chemotherapy of acute leukemia. Comparison of cytarabine alone and in combination with vincristine, prednisone, and cyclophosphamide.
复制标题
急性白血病的化疗。
DOI：
10.1001/archinte.1974.00320140098010
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发表时间：
1974
影响因子：
--
通讯作者：
H. Wilson
中科院分区：
文献类型：
--
作者：
G. Bodey;C. Coltman;E. Freireich;J. Bonnet;E. Gehan;A. Haut;J. Hewlett;K. B. McCredit;J. Saiki;H. Wilson
在123例急性白血病患者的研究中，将由硫酸长春新碱、强的松、阿糖胞苷和环磷酰胺(COAP)组成的方案与单用阿糖胞苷进行了比较。在接受COAP方案的66名患者中，32名患者完全缓解，相比之下，57名单独接受阿糖胞苷治疗的患者中有18名获得完全缓解。接受充分化疗试验的患者的完全缓解率分别为74%和49%。接受COAP方案的患者完全缓解的中位持续时间为62周，而单独接受阿糖胞苷的患者的完全缓解时间的中位数为46周。接受治疗的所有患者的中位生存期，COAP方案为35周，单用阿糖胞苷为8周。COAP方案对成人急性白血病是有效和安全的，可能优于单独使用阿糖胞苷，特别是对年龄超过35岁的患者。年长的。
A regimen consisting of vincristine sulfate, prednisone, cytarabine, and cyclophosphamide (COAP) has been compared with cytarabine alone in a study of 123 patients with acute leukemia. Of the 66 patients receiving the COAP regimen, 32 achieved complete remission compared to 18 of the 57 patients who received cytarabine alone. The complete remission rates for patients receiving an adequate trial of chemotherapy were 74% and 49%, respectively. The median duration of complete remission was 62 weeks for patients receiving the COAP regimen and 46 weeks for patients receiving cytarabine alone. The median duration of survival for all patients entered on therapy was 35 weeks for the COAP regimen and 8 weeks for cytarabine alone. The COAP regimen is effective and safe for adults with acute leukemia and is probably superior to cytarabine alone, especially in patients who are more than 35 years. old.