High frequency of false positive IgM immunoblots for Borrelia burgdorferi in Clinical Practice
High frequency of false positive IgM immunoblots for Borrelia burgdorferi in Clinical Practice
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DOI：
10.1111/j.1469-0691.2011.03749.x
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发表时间：
2012-12-01
影响因子：
14.2
通讯作者：
Wormser, G. P.
中科院分区：
文献类型：
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作者：
Seriburi, V.;Ndukwe, N.;Wormser, G. P.
虽然已知莱姆病的两级血清学检测可能与IgM免疫印迹的假阳性结果相关，但该问题从未在临床实践环境中进行过系统研究。在一项回顾性调查中，182例患者中有50例（27.5%，95%CI：21.134.6）被发现有假阳性IgM免疫印迹。78.0%的患者接受了不必要的抗生素治疗。假阳性结果不限于任何单一的商业实验室。有必要研究完全消除IgM免疫印迹的替代检测策略。
Although it is known that two-tier serologic testing for Lyme disease may be associated with false positive results on the IgM immunoblot, this problem has never been systematically studied in the clinical practice setting. In a retrospective investigation of patients referred to the private adult practice of an Infectious Diseases physician for possible for Lyme disease, 50 of 182 patients (27.5%, 95% CI: 21.134.6) were found to have a false positive IgM immunoblot. 78.0% of these patients had received unnecessary antibiotic therapy. False positive results were not restricted to any single commercial laboratory. Research on alternative testing strategies that eliminate the IgM immunoblot entirely is warranted.