Biosynthesis, Modification and Processing of Viral Polyproteins
Biosynthesis, Modification and Processing of Viral Polyproteins
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病毒多蛋白的生物合成、修饰和加工
DOI：
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发表时间：
1982
期刊：
影响因子：
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通讯作者：
C. Weber
中科院分区：
文献类型：
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作者：
G. Koch;F. Koch;J. Bilello;E. Hiller;Claudia Schârli;G. Warnecke;C. Weber
几种细胞和许多病毒蛋白的生物合成伴随着对初级翻译产物的修饰（如磷酸化、羟基化、糖基化、ADP核糖基化、聚ADP核糖基化、乙酰化）和蛋白水解加工。修饰和加工既可以发生在多肽链延伸期间，也可以发生在蛋白质合成完成后很长一段时间内（评论见1-12）。例如，糖基化（13），特别是膜蛋白的糖基化和羟基化（胶原蛋白，参考文献14）发生在新生多肽链上。类似地，特定的蛋白水解加工形式，例如从膜蛋白和分泌蛋白中去除前导序列（15-20），以及小核糖核酸多蛋白裂解为三种不同的前体蛋白，都发生在伸长期间（11b, c, d）。
The biosynthesis of several cellular and many viral proteins is accompanied by modification (e.g. phosphorylation, hydroxylation, glycosylation, ADP ribosylation, poly ADP ribosylation, acetylation) and proteolytic processing of the primary translation product. Both modification and processing can take place during polypeptide chain elongation, as well as long after the completion of protein synthesis (for reviews see 1–12). By way of example, glycosylation (13), especially of membrane proteins and hydroxylation (collagen, ref. 14) occurs on nascent polypeptide chains. Similarly, forms of specific proteolytic processing, e.g. removal of the leader sequence from membrane and secretory proteins (15–20), and cleavage of the picornavirus polyproteins to three distinct precursor proteins occur during elongation (11b, c, d).