Elevation of serum adiponectin levels in Basedow disease.
Elevation of serum adiponectin levels in Basedow disease.
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DOI：
10.1016/j.metabol.2005.05.011
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发表时间：
2005-11
期刊：
影响因子：
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通讯作者：
Takako Saito;T. Kawano;Tomoyuki Saito;A. Ikoma;K. Namai;H. Tamemoto;M. Kawakami;S. Ishikawa
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文献类型：
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作者：
Takako Saito;T. Kawano;Tomoyuki Saito;A. Ikoma;K. Namai;H. Tamemoto;M. Kawakami;S. Ishikawa
本研究旨在确定甲状腺激素是否影响巴塞杜病患者的血清脂联素水平。对 64 名巴塞杜病患者进行了检查；甲状腺功能亢进状态患者32例，甲状腺功能正常状态患者32例，但均接受过抗甲状腺药物治疗。此外，30 名年龄和性别匹配的受试者作为对照。测定血清脂联素、游离T4、游离T3、促甲状腺激素和促甲状腺激素受体抗体（TRAb）。甲状腺功能亢进状态下的血清脂联素水平为 12.9 ± 1.6 μg/mL，该值显着高于甲状腺功能正常状态下的 8.2 ± 0.5 μg/mL (P < .05) 和对照受试者的 8.6 ± 0.7 μg/mL (P < .05)。血清脂联素水平与血清游离 T4 (r = 0.453，P < .001)、游离 T3 (r = 0.47，P < .001) 或 TRAb (r = 0.491，P < .001) 呈正相关，但与体重指数无关。多元回归分析显示，TRAb 对巴塞杜病患者血清脂联素浓度的贡献最强。目前的研究结果表明，高脂联素血症与巴杜病中血清甲状腺激素水平和 TRAb 的升高密切相关。
The present study was undertaken to determine whether thyroid hormone affects serum adiponectin levels in the patients with Basedow disease. Sixty-four patients with Basedow disease were examined; 32 patients had hyperthyroid state and 32 patients had euthyroid state who had been treated with antithyroid drugs. In addition, 30 age- and sex-matched subjects served as a control. Serum adiponectin, free T4, free T3, thyroid-stimulating hormone, and thyroid-stimulating hormone receptor antibody (TRAb) were measured. Serum adiponectin levels were 12.9 ± 1.6 μg/mL in the hyperthyroid state, a value significantly greater than that of 8.2 ± 0.5 μg/mL in the euthyroid state (P < .05) and that of 8.6 ± 0.7 μg/mL in the control subjects (P < .05). Serum adiponectin levels had positive correlations with either of serum free T4 (r = 0.453, P < .001), free T3 (r = 0.47, P < .001), or TRAb (r = 0.491, P < .001), but not with body mass index. Multiple regression analysis showed TRAb had the strongest contribution to serum adiponectin concentration in the patients with Basedow disease. The present findings indicate that hyperadiponectinemia is closely associated with increases in serum thyroid hormone levels and TRAb in Basedow disease.