Epidemiology of non-erosive reflux disease
Epidemiology of non-erosive reflux disease
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DOI：
10.1159/000151249
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发表时间：
2008-01-01
期刊：
影响因子：
3.2
通讯作者：
El-Serag, Hashem B.
中科院分区：
文献类型：
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作者：
El-Serag, Hashem B.
非糜烂性反流病 (NERD) 是一个相对较新的疾病，其定义一直在演变，涉及症状、内窥镜检查以及反流或反流相关损害的客观证据。现有流行病学研究发现，与 NERD 最接近的实体是在不存在食管糜烂或巴雷特食管的情况下出现胃食管反流病 (GERD) 症状。在这篇综述中，我确定了两项基于人群的研究、一项非社区研究和几项基于内窥镜检查的研究，这些研究提供了 NERD 多个方面的信息。大多数 GERD 是 NERD (50-85%)，因此可以估计一般人群中有 11-12%，并且接受内窥镜检查的患者比例 (37-87%) 可能患有 NERD，比例要高得多。 NERD 的危险因素包括无食管裂孔疝、低体重指数和幽门螺杆菌的存在，表明它是 GERD 谱系中“较温和”的部分。 NERD 的其他关联包括年龄较小、女性以及与功能性肠道疾病类似的心理合并症。 NERD 的时间趋势尚不清楚，并且可能会随着 GERD 症状患病率的增加而增加。版权所有 (C) 2008 S. Karger AG，巴塞尔。
Non-erosive reflux disease (NERD) is a relatively new entity, the definition of which has been evolving and involves the use of symptoms, endoscopy, and objective evidence of reflux or reflux-related damage. The closest entity to NERD that is examined by available epidemiologic studies is defined by the presence of gastroesophageal reflux disease (GERD) symptoms in the absence of esophageal erosions or Barrett's esophagus. In this review, I identified two populationbased studies, one non-community study, and several endoscopy-based studies that provided information on several aspects of NERD. Most of GERD is NERD (50-85%), and therefore one can estimate 11-12% of the general pop ulation and considerably higher proportions of patients presenting to endoscopy (37-87%) may have NERD. Risk factors for NERD including absence of hiatus hernia, low BMI, and presence of Helicobacter pylori indicate that it is a 'milder' part of the GERD spectrum. Other associations of NERD include younger age, female sex, and psychological comorbidities that resemble those of functional gut disorders. The temporal trends in NERD are unclear, and are probably increasing because GERD symptom prevalence has increased. Copyright (C) 2008 S. Karger AG, Basel.