Early pregnancy fasting plasma glucose and lipid concentrations in pregnancy and association to offspring size: a retrospective cohort study.
Early pregnancy fasting plasma glucose and lipid concentrations in pregnancy and association to offspring size: a retrospective cohort study.
复制标题
妊娠早期空腹血浆葡萄糖和脂质浓度及其与后代大小的关系：一项回顾性队列研究
DOI：
10.1186/s12884-016-0846-7
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发表时间：
2016-03-17
影响因子：
3.1
通讯作者：
Wang Z
中科院分区：
文献类型：
--
作者：
Liu B;Geng H;Yang J;Zhang Y;Deng L;Chen W;Wang Z
研究背景首次产前就诊时的高脂血症和高空腹血糖水平均与妊娠期糖尿病、母亲肥胖/超重和胎儿生长过长有关。本研究的目的是调查首次就诊的空腹血糖与血脂浓度的相关性，以及它们与分娩时胎儿大小的潜在关联。材料和方法2013年在我中心接受常规产前护理并分娩的孕妇被招募为研究对象。在第一次产前检查(第一次检查空腹血糖)和分娩前(分娩前空腹血糖)检测空腹血糖水平。在OGTT试验时检测糖化血红蛋白和血脂。收集产妇和新生儿的临床资料进行分析。数据分析采用独立样本检验、皮尔逊相关分析和卡方检验，然后进行偏相关分析和多元线性回归分析以确定相关性。统计学意义水平α=0.05。结果1546对母婴资料进行分析。调整孕妇孕前BMI、孕妇年龄和初诊胎龄后，首次就诊空腹血糖与任何血脂参数均无相关性。在调整了孕妇年龄和OGTT时孕妇BMI后，在整个队列和NGT组中，HbA1c与甘油三酯和载脂蛋白B呈正相关。多元线性回归分析显示，新生儿出生体重、头围、肩围均与初诊空腹血糖、甘油三酯水平相关。结论初诊空腹血糖与孕中期血脂水平无关，但与甘油三酯水平共同影响胎儿生长发育。
BackgroundHyperlipidemia and high fasting plasma glucose levels at the first prenatal visit (First Visit FPG) are both related to gestational diabetes mellitus, maternal obesity/overweight and fetal overgrowth. The purpose of the present study is to investigate the correlation between First Visit FPG and lipid concentrations, and their potential association with offspring size at delivery.Materials and methodsPregnant women that received regular prenatal care and delivered in our center in 2013 were recruited for the study. Fasting plasma glucose levels were tested at the first prenatal visit (First Visit FPG) and prior to delivery (Before Delivery FPG). HbA1c and lipid profiles were examined at the time of OGTT test. Maternal and neonatal clinical data were collected for analysis. Data was analyzed by independent samplettest, Pearson correlation, and Chi-square test, followed by partial correlation and multiple linear regression analyses to confirm association. Statistical significance level wasα=0.05.ResultsAnalyses were based on 1546 mother-baby pairs. First Visit FPG was not correlated with any lipid parameters after adjusting for maternal pregravid BMI, maternal age and gestational age at First Visit FPG. HbA1c was positively correlated with triglyceride and Apolipoprotein B in the whole cohort and in the NGT group after adjusting for maternal age and maternal BMI at OGTT test. Multiple linear regression analyses showed neonatal birth weight, head circumference and shoulder circumference were all associated with First Visit FPG and triglyceride levels.ConclusionFasting plasma glucose at first prenatal visit is not associated with lipid concentrations in mid-pregnancy, but may influence fetal growth together with triglyceride concentration.