A family study of obsessive-compulsive disorder.
A family study of obsessive-compulsive disorder.
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DOI：
10.1176/ajp.152.1.76
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
D. Pauls;J. Alsobrook;W. Goodman;S. Rasmussen;J. Leckman
中科院分区：
文献类型：
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作者：
D. Pauls;J. Alsobrook;W. Goodman;S. Rasmussen;J. Leckman
目的 本研究的目的是确定 1) 强迫症是否具有家族性，2) 强迫症与抽动秽语综合征和慢性抽动症之间是否存在家族关系，以及 3) 是否存在不同家族类型的强迫症。方法 在这项家庭研究中，100 名患有强迫症的先证者的所有一级亲属都接受了结构化访谈的直接采访，并分配了最佳估计诊断。除了先证者的 466 名一级亲属之外，还通过相同的访谈对 113 名对照受试者进行了研究，他们是 33 名未患精神疾病的受试者的一级亲属。结果 患有强迫症的先证者亲属中强迫症和阈下强迫症的发生率（分别为10.3%和7.9%）显着高于对照组（分别为1.9%和2.0%）。此外，先证者亲属的抽动症（抽动秽语症和慢性抽动症）发生率（4.6%）也显着高于对照组（1.0%）。患有强迫症的女性先证者的亲属更容易发生抽动，而早发型先证者的亲属发生强迫症和抽动的风险更高。结论 强迫症是一种异质性疾病。有些病例是家族性的，与抽动症有关，有些病例是家族性的，与抽动症无关，还有一些病例似乎没有强迫症或抽动症的家族史。
OBJECTIVE The goal of this study was to determine 1) whether obsessive-compulsive disorder is familial, 2) whether there is a familial relationship between obsessive-compulsive disorder and Gilles de la Tourette's syndrome and chronic tics, and 3) whether different familial types of obsessive-compulsive disorder exist. METHOD In this family study, all available first-degree relatives of 100 probands with obsessive-compulsive disorder were interviewed directly with structured interviews, and best-estimate diagnoses were assigned. In addition to the 466 first-degree relatives of the probands, 113 comparison subjects who were first-degree relatives of 33 psychiatrically unaffected subjects were studied with the same interviews. RESULTS The rates of obsessive-compulsive disorder and subthreshold obsessive-compulsive disorder were significantly greater among the relatives of the probands with obsessive-compulsive disorder (10.3% and 7.9%, respectively) than among the comparison subjects (1.9% and 2.0%, respectively). Furthermore, the rate of tics (Tourette's disorder and chronic tics) was also significantly greater among the relatives of the probands (4.6%) than among the comparison subjects (1.0%). The relatives of female probands with obsessive-compulsive disorder were more likely to have tics, and the relatives of probands with early onset were at higher risk for both obsessive-compulsive disorder and tics. CONCLUSIONS Obsessive-compulsive disorder is a heterogeneous condition. Some cases are familial and related to tic disorders, some cases are familial and unrelated to tics, and in other cases there appears to be no family history of either obsessive-compulsive disorder or tics.