Low Plasma 25-Hydroxyvitamin D and Risk of Tobacco-Related Cancer
Low Plasma 25-Hydroxyvitamin D and Risk of Tobacco-Related Cancer
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DOI：
10.1373/clinchem.2012.201939
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发表时间：
2013-05-01
影响因子：
9.3
通讯作者：
Nordestgaard, Borge G.
中科院分区：
文献类型：
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作者：
Afzal, Shoaib;Bojesen, Stig E.;Nordestgaard, Borge G.
背景：烟草烟雾化学物质可能会影响维生素D的代谢和功能，反之，维生素D可能会改变烟草烟雾化学物质的致癌性。我们测试了这一假设，即血浆25-羟基维生素D[25(OH)D]水平较低与普通人群中烟草相关癌症的风险较高有关。方法：从1981-1983年到2008年12月，我们对哥本哈根城市心脏研究中9791名基线无癌症的前瞻性人群队列进行了跟踪调查，并进行了100%的完全随访。结果：在长达28年的随访中，1081名参与者患上了烟草相关癌症，1506人患上了其他癌症。按临床类别或经季节调整的百分位数类别细分的25(OH)D浓度降低与烟草相关癌症累积发病率的增加相关(对数趋势P=2×10(-6)和P=5×10(-9))。与烟草相关的癌症的多变量调整风险比为1.75(95%CI，1.33-2.30)，25(OH)D<；5vs>；=20 ng/mL，66百分位数为2.07(1.63-2.62)。此外，25(OH)D降低50%的多变量调整风险比为：任何与烟草有关的癌症1.20(1.13-1.28)，肺癌1.19(95%CI，1.09-1.31)，头颈癌1.44(1.19-1.73)，膀胱癌1.28(1.06-1.54)，肾癌1.34(1.04-1.73)，其他癌症的风险为0.95(0.89~1.01)。结论：较低的血浆25(OH)D水平与患烟草相关癌症的风险较高，但与其他癌症的风险无关。(C)2013年美国临床化学协会
BACKGROUND: Tobacco smoke chemicals may influence vitamin D metabolism and function, and conversely vitamin D may modify the carcinogenicity of tobacco smoke chemicals. We tested the hypothesis that lower plasma 25-hydroxyvitamin D [25(OH)D] is associated with a higher risk of tobacco-related cancer in the general population.METHODS: A prospective population-based cohort of 9791 individuals from the Copenhagen City Heart Study who were free of cancer at baseline was followed from 1981-1983 until December 2008 with 100% complete follow-up.RESULTS: During up to 28 years of follow-up, 1081 participants developed a tobacco-related cancer and 1506 developed other cancers. Decreasing 25(OH) D concentrations, subdivided by clinical categories or by seasonally adjusted percentile categories, were associated with increasing cumulative incidence of tobacco-related cancer (log-rank trend P = 2 X 10(-6) and P = 5 X 10(-9)). Multivariable adjusted hazard ratios of tobacco-related cancer were 1.75 (95% CI, 1.33-2.30) for 25(OH) D < 5 vs >= 20 ng/mL, and 2.07 (1.63-2.62) for 66th percentile. Also, multivariable adjusted hazard ratios for a 50% reduction in 25(OH) D were 1.20 (1.13-1.28) for any tobacco-related cancer, 1.19 (95% CI, 1.09-1.31) for lung cancer, 1.44 (1.19-1.73) for head and neck cancer, 1.28 (1.06-1.54) for bladder cancer, 1.34 (1.04-1.73) for kidney cancer, and 0.95 (0.89-1.01) for other cancers.CONCLUSIONS: Lower plasma 25(OH) D was associated with higher risk of tobacco-related cancers, but not with risk of other cancers. (C) 2013 American Association for Clinical Chemistry