Tea crude extracts effectively inactivate severe acute respiratory syndrome coronavirus 2
Tea crude extracts effectively inactivate severe acute respiratory syndrome coronavirus 2
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DOI：
10.1111/lam.13591
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发表时间：
2021-11-05
影响因子：
2.4
通讯作者：
Yamasaki, S.
中科院分区：
文献类型：
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作者：
Ishimoto, K.;Hatanaka, N.;Yamasaki, S.
众所周知，红茶和绿色茶提取物，特别是多酚类，对包括病毒在内的各种病原微生物具有抗微生物活性。然而，关于针对严重急性呼吸综合征冠状病毒2型（SARS-CoV-2）的抗病毒活性的数据有限，该病毒于2019年底在中国迅速出现，并导致全球2019冠状病毒病（COVID-19）大流行。在这项研究中，从红茶和绿色茶中获得了20种化合物和三种提取物，发现三种茶提取物对SARS-CoV-2显示出显著的抗病毒活性，其中当在25 ℃下孵育10 s时，通过1个中心点375 mg/ml（-1）红茶提取物和从红茶获得的两倍稀释的茶袋浸泡液，病毒滴度降低约5 log TCID 50/ml。然而，当红茶和绿色茶提取物的浓度相等地调节到344 μ g/ml（-1）时，绿色茶提取物显示出更强的抗SARS-CoV-2的抗病毒活性。这种简单而备受推崇的饮料可能是发达国家和发展中国家减少口腔、上消化道和呼吸道中SARS-CoV-2病毒负担的廉价且广泛接受的方法。
It is well known that black and green tea extracts, particularly polyphenols, have antimicrobial activity against various pathogenic microbes including viruses. However, there is limited data on the antiviral activity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which emerged rapidly in China in late 2019 and which has been responsible for coronavirus disease 2019 (COVID-19) pandemic globally. In this study, 20 compounds and three extracts were obtained from black and green tea and found that three tea extracts showed significant antiviral activity against SARS-CoV-2, whereby the viral titre decreased about 5 logs TCID50 per ml by 1 center dot 375 mg ml(-1) black tea extract and two-fold diluted tea bag infusion obtained from black tea when incubated at 25 degrees C for 10 s. However, when concentrations of black and green tea extracts were equally adjusted to 344 mu g ml(-1), green tea extracts showed more antiviral activity against SARS-CoV-2. This simple and highly respected beverage may be a cheap and widely acceptable means to reduce SARS-CoV-2 viral burden in the mouth and upper gastrointestinal and respiratory tracts in developed as well as developing countries.