Matrix metalloproteinases in destructive lung disease
Matrix metalloproteinases in destructive lung disease
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DOI：
10.1016/j.matbio.2015.02.002
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发表时间：
2015-05-01
期刊：
影响因子：
6.9
通讯作者：
Houghton, A. McGarry
中科院分区：
文献类型：
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作者：
Houghton, A. McGarry
基质金属蛋白酶(MMPs)在从发育到创面修复的许多过程中发挥着重要的生理作用。不幸的是，由于基质金属蛋白酶家族作为一个整体具有广泛的底物特异性，细胞外基质蛋白的异常降解可能导致破坏性疾病。肺气肿是肺弹性蛋白和胶原基质被破坏的结果，是这种破坏性过程的典型例子。最近的数据表明，与简单的基质蛋白切割相比，MMPs发挥着更复杂的生理和病理生理学作用。本文将讨论MMPs在肺气肿中的关键病理生理学作用。(C)由爱思唯尔出版的2015年。
Matrix metalloproteinases (MMPs) play essential physiologic roles in numerous processes ranging from development to wound repair. Unfortunately, given the broad substrate specificity of the MMP family as a whole, aberrant degradation of extracellular matrix proteins can result in destructive disease. Emphysema, the result of destroyed lung elastin and collagen matrix, is the prototypical example of such a destructive process. More recent data has highlighted that MMPs play much more elaborate physiologic and pathophysiologic roles than simple matrix protein cleavage. Key pathophysiological roles for MMPs in emphysema will be discussed herein. (C) 2015 Published by Elsevier B.V.