Shift in Japanese encephalitis virus (JEV) genotype circulating in northern Vietnam: implications for frequent introductions of JEV from Southeast Asia to East Asia
Shift in Japanese encephalitis virus (JEV) genotype circulating in northern Vietnam: implications for frequent introductions of JEV from Southeast Asia to East Asia
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DOI：
10.1099/vir.0.79797-0
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发表时间：
2004-06-01
影响因子：
3.8
通讯作者：
Morita, K
中科院分区：
文献类型：
--
作者：
Nga, PT;Parquet, MD;Morita, K
本研究使用E基因序列数据分析了16株日本脑炎病毒（JEV）分离株（9株来自越南，7株来自日本）与先前发表的JEV毒株的进化相关性。1986年至1990年间分离的越南和日本菌株被发现聚集在基因型3中。然而，1995年至2002年期间分离的越南和日本菌株属于基因型1，目前在越南占主导地位，但以前未报告基因型。此外，在这项研究中，1995年至2002年之间分离的菌株与20世纪90年代分离的菌株的关系比与较老的基因型1菌株的关系更密切。最近，日本和韩国也报道了JEV基因型1的引入。因此，这种基因型转移现象可能发生在整个东亚。需要进一步研究JEV生态学，以阐明JEV基因1型向新领土传播的机制。
This study analyses the evolutionary relatedness of 16 Japanese encephalitis virus (JEV) isolates (nine from Vietnam and seven from Japan) to previously published JEV strains using E gene sequence data. Vietnamese and Japanese strains isolated between 1986 and 1990 were found to cluster in genotype 3. However, more recent Vietnamese and Japanese strains isolated between 1995 and 2002 grouped within genotype 1, now a dominant though previously unreported genotype in Vietnam. In addition, in this study, strains isolated between 1995 and 2002 were more closely related to those isolated in the 1990s than to the older genotype 1 strains. Recently, the introduction of JEV genotype 1 into Japan and Korea has also been reported. Hence this genotype shift phenomenon may be occurring throughout all East Asia. Further studies on JEV ecology are needed to clarify the mechanism of JEV genotype 1 spread to new territories.