DETAILED TOXICITY STUDIES OF LIPOSOMAL GADOLINIUM-DTPA
DETAILED TOXICITY STUDIES OF LIPOSOMAL GADOLINIUM-DTPA
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DOI：
10.1097/00004424-199111000-00007
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发表时间：
1991-11-01
影响因子：
6.7
通讯作者：
TILCOCK, C
中科院分区：
文献类型：
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作者：
FRITZ, T;UNGER, E;TILCOCK, C
在小鼠中评估脂质体钆-DTPA（Gd-DTPA）、空白脂质体和非脂质体Gd-DTPA的急性、亚急性和迟发毒性试验。在亚急性实验中，小鼠每天静脉注射（IV）0.3 mmol/kg Gd-DTPA，持续30天，注射形式为游离Gd-DTPA、脂质体Gd-DTPA或不含Gd-DTPA的空白脂质体中的等量脂质。脂质体和非脂质体Gd-DTPA的内插急性LD 50（估计为确定近似水平的方法）相似（LD 50 = 5.7 mmol/kg Gd-DTPA）。亚急性毒性试验中，长期大剂量给药可引起脾肿大、心脏肿大、淋巴细胞减少和高丙种球蛋白血症（P <0.05）。非脂质体Gd-DTPA引起轻度心脏肥大和肝酶改变（P <0.05）。空白脂质体引起相对轻度的脾肿大（P <0.05），但几乎没有其他变化。亚急性试验后三个月的延迟试验表明，脂质体Gd-DTPA引起的大部分变化是可逆的。
Acute, subacute, and delayed toxicity testing was assessed in mice for liposomal gadolinium-DTPA (Gd-DTPA), blank liposomes, and nonliposomal Gd-DTPA. In the subacute experiments mice were injected intravenously (IV) with 0.3 mmol/kg Gd-DTPA per day for 30 days in the form of either free Gd-DTPA, liposomal Gd-DTPA, or an equivalent amount of lipid in blank liposomes without Gd-DTPA. The interpolated acute LD50 of liposomal and nonliposomal Gd-DTPA, estimated as a means of identifying the approximate level, was similar (LD50 = 5.7 mmol/kg Gd-DTPA). In subacute toxicity testing, prolonged high doses of liposomal Gd-DTPA caused splenomegaly, cardiomegaly, lymphocytopenia and hypergammaglobulinemia (P < .05). Nonliposomal Gd-DTPA caused mild cardiomegaly and altered liver enzymes (P < .05). Blank liposomes caused relatively mild splenomegaly (P < .05) but few other changes. Delayed testing three months after the subacute testing showed that most of the changes caused by the liposomal Gd-DTPA were reversible.