HEPATITIS-B VACCINATION - 3 DECISION STRATEGIES FOR THE INDIVIDUAL
HEPATITIS-B VACCINATION - 3 DECISION STRATEGIES FOR THE INDIVIDUAL
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DOI：
10.1016/0002-9343(84)90182-7
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发表时间：
1984-01-01
影响因子：
5.9
通讯作者：
RANSOHOFF, DF
中科院分区：
文献类型：
--
作者：
LITTENBERG, B;RANSOHOFF, DF
通过决策分析比较了关于B型肝炎病毒疫苗接种的策略（3）：不接种、立即接种和2年后接种。等待2年的潜在优势是了解严重的疫苗副作用是否会变得明显。例如，对10万名年发病率为5%的外科医院工作人员立即接种B型肝炎疫苗5年，与不接种相比，可预防4092例黄疸型肝炎、335例慢性活动性肝炎和15例暴发性肝炎死亡。对于等待2年的策略，预防的病例数将减少约. apprx。百分之四十年发病率< 5%的人群似乎从接种疫苗中获益。已知的B型肝炎病毒疫苗接种的健康风险很低，假设的风险必须很频繁才能证明延迟接种疫苗是合理的。从个人的角度来看，即使是B型肝炎病毒感染风险较低的人也应该认真考虑立即接种疫苗。
Strategies (3) regarding hepatitis B virus vaccination were compared by decision analysis: no vaccination, immediate vaccination and vaccination after 2 yr. The potential advantage of waiting 2 yr is to learn whether serious vaccine side effects will become evident. For example, immediate hepatitis B vaccination of 100,000 surgical house officers with a 5% annual attack rate for 5 yr would, compared with no vaccination, prevent 4092 cases of icteric hepatitis, 335 cases of chronic active hepatitis and 15 deaths from fulminant hepatitis. For a strategy of waiting 2 yr, the number of cases prevented would decrease by .apprx. 40%. Persons in groups with an annual attack rate < 5% appear to benefit from vaccination. The known health risks of hepatitis B virus vaccination are low, and the hypothesized risks would have to be frequent to justify delay in vaccination. From an individual perspective, even persons at low hepatitis B virus infection risk should seriously consider immediate vaccination.