Extracellular phospholipase A2.
Extracellular phospholipase A2.
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细胞外磷脂酶A2。
DOI：
10.1007/978-1-4615-3426-6_4
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发表时间：
1992
影响因子：
--
通讯作者：
Yu,L
中科院分区：
文献类型：
--
作者：
Dennis,EA;Deems,RA;Yu,L
多种脂质与信号转导有关并作为脂质介质的前体，其中包括花生四烯酸（Dennis 等，1991）。通过环氧合酶途径产生前列腺素、血栓素和前列环素，以及通过脂氧合酶途径产生白三烯和脂氧素，都取决于游离花生四烯酸的可用性。如图 1 所示，对游离花生四烯酸产生的控制被认为涉及尚未定义的膜受体事件（Dennis，1989）。据推测，该事件涉及直接或通过介质激活磷脂酶。据推测，这种磷脂酶与膜相关或在易位后变得如此（Channon 和 Leslie，1990）。由于大部分细胞花生四烯酸在膜磷脂的 sn-2 位被酯化，因此磷脂酶 A2 是最简单、最合理的酶
Various lipids have been implicated in signal transduction and as precursors of lipid mediators, among them arachidonic acid (Dennis et al., 1991). Production of the prostaglandins, thromboxanes, and prostacyclins via the cyclooxygenase pathway, as well as the production of the leukotrienes and lipoxins via the lipoxygenase pathway, all depend on the availability of free arachidonic acids. As illustrated in Figure 1, control of the production of free arachidonic acid is believed to involve an as yet undefined membrane receptor event (Dennis, 1989). Presumably this event involves the activation of a phospholipase, either directly or through mediators. Presumably this phospholipase is membrane associated or becomes so after translocation (Channon and Leslie, 1990). Because the bulk of cellular arachidonic acid is found esterified in thesn-2position of membrane phospholipids, a phospholipase A2is the simplest and most logical enzyme