Visual disturbances in cystic fibrosis following chloramphenicol administration.
Visual disturbances in cystic fibrosis following chloramphenicol administration.
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氯霉素给药后囊性纤维化引起的视觉障碍。
DOI：
10.1016/s0022-3476(66)80420-1
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发表时间：
1965
期刊：
影响因子：
--
通讯作者：
Ann Sproul
中科院分区：
文献类型：
--
作者：
Nancy N. Huang;Robison D. Harley;V. Promadhattavedi;Ann Sproul
33 名长期接受氯霉素治疗的囊性纤维化患者中，有 9 名出现视神经炎和球后神经炎并伴有明显的视力障碍。两名患者出现严重视力障碍和永久性残留效应，并伴有部分视神经萎缩。维生素 B 复合物已被证明在某些情况下具有治疗作用。人们认为视力障碍可能代表氯霉素的神经毒性作用，而不是囊性纤维化的并发症。所有接受长期氯霉素治疗的囊性纤维化患者必须经常进行视力检查并定期进行眼科检查。
Optic neuritis and retrobulbar neuritis with marked visual impairment occurred in 9of 33 patients with cystic fibrosis, who received long-term therapy with chloramphenicol. Two patients had severe visual impairment and permanent residual effects with partial optic atrophy. Vitamin B complex has been demonstrated to be therapeutic in some instances. It is thought that the visual impairment probably represents a neurotoxic effect of chloramphenicol rather than a complication of cystic fibrosis. All patients with cystic fibrosis who receive long-term therapy with chloramphenicol must have frequent tests for visual acuity and periodic ophthalmologic examinations.