Effects of one year of supplementation with zinc and other micronutrients on cellular immunity in the elderly.
Effects of one year of supplementation with zinc and other micronutrients on cellular immunity in the elderly.
复制标题
补充锌和其他微量营养素一年对老年人细胞免疫的影响。
DOI：
10.1080/07315724.1990.10720372
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发表时间：
1990
影响因子：
3.5
通讯作者：
Holland,BK
中科院分区：
文献类型：
--
作者：
Bogden,JD;Oleske,JM;Lavenhar,MA;Munves,EM;Kemp,FW;Bruening,KS;Holding,KJ;Denny,TN;Guarino,MA;Holland,BK
本研究的目的是确定一年的锌补充对锌浓度在循环细胞和细胞免疫功能的老年人。受试者年龄在60-89岁之间，每天给予安慰剂、15 mg Zn或100 mg Zn，持续12个月。所有受试者还接受了不含额外锌的多种维生素/矿物质补充剂。在开始补锌前和补锌后3、6、12和16个月抽取血液样本并评估免疫功能。还在每次访视时评估受试者饮食。膳食叶酸、吡哆醇、α-生育酚、铜、锌和镁的摄入量始终低于推荐摄入量。虽然在100毫克锌治疗组的血浆锌显着增加，锌在红细胞，单核细胞，多形核白细胞和血小板的浓度没有显着增加补锌。自然杀伤细胞活性被瞬时增强100毫克/天剂量的锌。迟发性皮肤超敏反应（DDH）和对两种有丝分裂原的淋巴细胞增殖反应有进展性改善;这可能是由于对所有研究受试者给予多种维生素/矿物质补充剂的一种或多种成分所致。安慰剂组DDH的增强显著大于锌治疗组。因此，锌对细胞免疫功能的一种测量具有有益作用，同时对细胞免疫的另一种测量具有不利作用。
The objective of this study was to determine the effects of a year of Zn supplementation on Zn concentrations in circulating cells and on cellular immune functions in the elderly. Subjects, aged 60-89, were given a placebo, 15 mg Zn, or 100 mg Zn daily for 12 months. All subjects also received a multivitamin/mineral supplement that contained no additional Zn. Blood samples were drawn and immune functions assessed prior to and at 3, 6, 12, and 16 months after beginning Zn supplementation. Subject diets were also assessed at each visit. Dietary folate, pyridoxine, alpha-tocopherol, copper, zinc, and magnesium were consistently below recommended intakes. Although plasma Zn increased significantly in the 100 mg Zn treatment group, concentrations of Zn in erythrocytes, mononuclear cells, polymorphonuclear leukocytes, and platelets were not significantly increased by zinc supplementation. Natural killer cell activity was transiently enhanced by the 100 mg/day dose of Zn. There was a progressive improvement in delayed dermal hypersensitivity (DDH) and in lymphocyte proliferative responses to two mitogens; this may have been due to one or more components of the multivitamin/mineral supplement administered to all study subjects. The enhancement of DDH was significantly greater in the placebo group than in either zinc treatment group. Thus, zinc had a beneficial effect on one measure of cellular immune function while simultaneously having an adverse effect on another measure of cellular immunity.