Relationship between input and output of cells in motor and somatosensory cortices of the chronic awake rat
Relationship between input and output of cells in motor and somatosensory cortices of the chronic awake rat
复制标题
慢性清醒大鼠运动皮质和体感皮质细胞输入与输出的关系
DOI：
10.1007/bf00238808
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发表时间：
1981
影响因子：
2
通讯作者：
D. Albe
中科院分区：
文献类型：
--
作者：
S. Sapienza;B. Talbi;J. Jacquemin;D. Albe
摘要使用相同的玻璃微电极 (6–8 MΩ) 进行记录和刺激的实验对 12 只大鼠进行，其中在运动和体感皮质区的 65 次穿透中研究了 379 个皮质细胞。为了避免麻醉作用，老鼠被长期植入由野田等人开发的头部系统。 （1971）。这些动物很好地接受了头部固定，因此可以很容易地研究外围感受野。在初步实验中，评估了给定刺激强度激活的锥体细胞的数量。在第 V 锥体层中始终观察到最低阈值强度，以及细胞输入和输出之间的对应关系。具有相同阈值的相同类型的组织存在于所谓的“运动”和“体感”皮质区中。当刺激非 PT 细胞附近（皮质表面以下 600-700 μm）时可以获得运动。然而，该水平的阈值较高，并且认为运动是由于刺激电流扩散到锥体束细胞层所致。
SummaryExperiments using the same glass microelectrode (6–8 MΩ) for recording and stimulating were performed on 12 rats in which 379 cortical cells were studied in 65 penetrations through the motor and somatosensory cortical zones. To avoid anaesthetic effects the rats were chronically implanted with a head system derived from the one developed by Noda et al. (1971). These animals well accepted head fixation and the peripheral receptive fields could thus be easily investigated. In a preliminary experiment the number of pyramidal cells activated by a given stimulus intensity was evaluated. The lowest threshold intensities were always observed in the Vth pyramidal layer, as well as correspondence between cell input and output. The same type of organization, with identical thresholds, existed in the so-called “Motor” and “Somatosensory” cortical zones. Movements could be obtained when stimulating near non-PT cells (600–700 μm below the cortical surface). However, thresholds were higher at this level and it is thought that the movements were due to a spread of the stimulating current to the pyramidal tract cell layer.