Detecting Anosognosia from the Prodromal Stage of Alzheimer's Disease.
Detecting Anosognosia from the Prodromal Stage of Alzheimer's Disease.
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从阿尔茨海默氏病的前驱阶段检测出厌食症。
DOI：
10.3233/jad-230552
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发表时间：
2023
影响因子：
4
通讯作者：
Andrade, Katia
中科院分区：
文献类型：
--
作者：
Guieysse, Thomas;Lamothe, Roxane;Houot, Marion;Razafimahatratra, Solofo;Medani, Takfarinas;Lejeune, Francois-Xavier;Dreyfus, Gerard;Klarsfeld, Andre;Pantazis, Dimitrios;Koechlin, Etienne;Andrade, Katia
关键词：
虽然最初不是为此目的而开发的，但健康老龄化脑护理监测仪（HABC-M）似乎是评估阿尔茨海默病（AD）病感失认症的有价值的工具。本研究的目的是：1）考察HABC-M量表的效度（31项）及其认知、心理和功能分量表在区分AD患者和对照组中的作用; 2）探讨患者/对照组在这些不同领域的自我报告与其照顾者/信息提供者提供的相应评级之间的HABC-M差异分数是否与自我意识的在线测量相关; 3）确定也从HABC-M导出的护理者负担水平是否可以为检测疾病感缺失增加额外的支持。对30例AD患者和30例健康对照者及其照顾者/知情者进行HABC-M管理。在线意识的测量是建立在一个计算机化的实验中，从受试者对他们的表现的估计。HABC-M差异评分区分AD患者和对照组。认知子量表将两组与前驱AD阶段区分开来，AUC为0.88 [95% CI：0.78;0.97]。加上照顾者负担水平，将其提高到0.94 [0.86;0.99]。在患者组中观察到HABC-M和在线差异评分之间的显著相关性，提供了这些方法的收敛效度。认知HABC-M（六项）可以检测整个AD谱的疾病感缺失。照顾者负担（四项）可能证实病感失认症的怀疑。由这10个项目而不是通常的31个项目构建的短混合量表显示出从前驱AD阶段检测疾病感缺失的最高灵敏度，这可能进一步有助于及时诊断。
Though not originally developed for this purpose, the Healthy Aging Brain Care Monitor (HABC-M) seems a valuable instrument for assessing anosognosia in Alzheimer’s disease (AD). Our study aimed at 1) investigating the validity of the HABC-M (31 items), and its cognitive, psychological, and functional subscales, in discriminating AD patients from controls; 2) exploring whether the HABC-M discrepancy scores between the self-reports of patients/controls in these different domains and the respective ratings provided by their caregivers/informants correlate with an online measure of self-awareness; 3) determining whether the caregiver burden level, also derived from the HABC-M, could add additional support for detecting anosognosia. The HABC-M was administered to 30 AD patients and 30 healthy controls, and to their caregivers/informants. A measure of online awareness was established from subjects’ estimation of their performances in a computerized experiment. The HABC-M discrepancy scores distinguished AD patients from controls. The cognitive subscale discriminated the two groups from the prodromal AD stage, with an AUC of 0.88 [95% CI: 0.78;0.97]. Adding the caregiver burden level raised it to 0.94 [0.86;0.99]. Significant correlations between the HABC-M and online discrepancy scores were observed in the patients group, providing convergent validity of these methods. The cognitive HABC-M (six items) can detect anosognosia across the AD spectrum. The caregiver burden (four items) may corroborate the suspicion of anosognosia. The short-hybrid scale, built from these 10 items instead of the usual 31, showed the highest sensitivity for detecting anosognosia from the prodromal AD stage, which may further help with timely diagnosis.
影响因子：
2.9
作者：
Klein TA;Danielmeier C;Ullsperger M
通讯作者：
Ullsperger M