Genome stability - Transgenerational mutation by radiation
Genome stability - Transgenerational mutation by radiation
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DOI：
10.1038/35011135
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发表时间：
2000-05-04
期刊：
影响因子：
64.8
通讯作者：
Jeffreys, AJ
中科院分区：
文献类型：
--
作者：
Dubrova, YE;Plumb, M;Jeffreys, AJ
父母暴露于电离辐射会增加在下一代中可检测到的生殖细胞突变的频率。父母受到辐射也会增加体细胞的突变率，并使后代易患癌症，这表明辐射可能对体细胞基因组的稳定性产生间接影响，这种影响可通过受辐射父母的生殖系传播。我们发现，这种间接影响延伸到未暴露的第一代小鼠后代的生殖系，如其后代中重复DNA序列不稳定性增加所揭示的。
Parental exposure to ionizing radiation increases the frequency of germline mutations detectable in the next generation. Parental exposure can also increase the rate of mutation in somatic cells,and confer a predisposition to cancer,,in offspring, suggesting that there could be an indirect effect of radiation on somatic genome stability that is transmissible through the germ line of the irradiated parents. We have found that this indirect effect extends to the germ line of unexposed first-generation offspring in mice, as revealed by an increased instability of repeat-DNA sequences in their descendants.