Prothrombotic Responses After Catheter Ablation for Atrial Fibrillation During Uninterrupted Oral Anticoagulant Agent Administration
Prothrombotic Responses After Catheter Ablation for Atrial Fibrillation During Uninterrupted Oral Anticoagulant Agent Administration
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DOI：
10.1016/j.jacep.2019.09.002
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发表时间：
2019-12-01
影响因子：
7
通讯作者：
Murohara, Toyoaki
中科院分区：
文献类型：
--
作者：
Yanagisawa, Satoshi;Inden, Yasuya;Murohara, Toyoaki
目的：本研究的目的是评估不间断口服抗凝剂（OAC）治疗心房颤动（AF）的导管消融后血栓形成前反应的变化程度。背景：房颤的导管消融有潜在的血栓前活化和无症状血栓栓塞事件的风险。方法共纳入814例心房颤动消融患者（n = 172例[华法林]，n = 153例[达比加群]，n = 134例[利伐沙班]，n = 301例[阿哌沙班]，对照组54例非心房颤动消融患者）。AF患者在手术过程中不间断地给予oac。术前和术后3天采集血样。结果在基线时，d -二聚体水平在正常范围内(
OBJECTIVES The aim of this study was to evaluate the extent of changes in prothrombotic responses after catheter ablation for atrial fibrillation (AF) under uninterrupted oral anticoagulant agent (OAC) administration.BACKGROUND Catheter ablation for AF has a potential risk for prothrombotic activation and silent thromboembolic events.METHODS A total of 814 patients (n = 172 [warfarin], n = 153 [dabigatran], n = 134 [rivaroxaban], and n = 301 [apixaban] patients undergoing AF ablation and a control group of 54 patients undergoing non-AF ablation) were included. Uninterrupted OACs were administered during the procedure in patients with AF. Blood samples were collected the day before and 3 days after the procedure.RESULTS At baseline, D-dimer levels were within normal limits (