Amiloride sensitivity of the chorda tympani response to sodium chloride in sodium-depleted Wistar rats.
Amiloride sensitivity of the chorda tympani response to sodium chloride in sodium-depleted Wistar rats.
复制标题
缺钠 Wistar 大鼠鼓索对氯化钠反应的阿米洛利敏感性。
DOI：
10.1037//0735-7044.106.4.722
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发表时间：
1992
影响因子：
1.9
通讯作者：
Taylor,EM
中科院分区：
文献类型：
--
作者：
Bernstein,IL;Taylor,EM
外周味觉机制可能影响钠（Na）食欲的表达，多年来一直是人们关注的焦点。由于阿米洛利敏感的钠转运参与了对NaCl刺激的神经信号的产生，因此本研究评估了大鼠对NaCl的神经反应中阿米洛利敏感性的变化是否伴随着Na食欲的诱导。钠剥夺是通过利尿剂速尿急性耗竭来实现的。与Na充满的大鼠相比，Na缺失的大鼠对0.5 M NaCl的全神经脊索反应减弱，这为之前的报道提供了有力的支持，即Na食欲的诱导与神经对NaCl的反应减弱有关。然而，对特定钠通道阻滞剂盐酸阿米洛利的敏感性变化并不明显。这些发现表明，钠耗尽后发生的行为和神经变化不是基于味蕾中阿米洛利敏感性的变化。
Peripheral gustatory mechanisms that may contribute to the expression of sodium (Na) appetite have been a focus of interest for many years. Because amiloride-sensitive Na transport is involved in the generation of neural signals in response to NaCl stimulation, the present study assessed whether changes in amiloride sensitivity of the neural response to NaCl accompany the induction of a Na appetite in the rat. Na deprivation was achieved by acute depletion with the diuretic furosemide. The magnitude of the whole-nerve chorda tympani response to 0.5 M NaCl was reduced in Na-depleted, compared with Na-replete, rats, which provides qualified support for previous reports that the induction of a Na appetite is associated with reduced neural responses to NaCl. However, changes in sensitivity to the specific Na channel blocker amiloride hydrochloride as a result of Na depletion were not evident. These findings suggest that the behavioral and neural changes that occur after Na depletion are not based on changes in amiloride sensitivity in the taste bud.