Microsatellite markers reveal a spectrum of population structures in the malaria parasite Plasmodium falciparum
Microsatellite markers reveal a spectrum of population structures in the malaria parasite Plasmodium falciparum
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DOI：
10.1093/oxfordjournals.molbev.a026247
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发表时间：
2000-10-01
影响因子：
10.7
通讯作者：
Day, KP
中科院分区：
文献类型：
--
作者：
Anderson, TJC;Haubold, B;Day, KP
微生物病原体的多位点基因分型揭示了一系列的群体结构，其中一些细菌显示出广泛的重组，而另一些细菌显示出几乎完全的克隆性。原生动物寄生虫恶性疟原虫的种群结构一直难以评估，因为大多数研究都使用了有限数量的抗原编码基因座，已知这些基因座处于强选择下。我们描述了从全球9个地点收集的465例感染中12个微卫星位点的长度变异。这些数据揭示了不同地点寄生虫种群结构的巨大差异。在9个群体中的6个中观察到强连锁不平衡（LD）。显著LD发生在所有患病率
Multilocus genotyping of microbial pathogens has revealed a range of population structures, with some bacteria showing extensive recombination and others showing almost complete clonality. The population structure of the protozoan parasite Plasmodium falciparum has been harder to evaluate, since most studies have used a limited number of antigen-encoding loci that are known to be under strong selection. We describe length variation at 12 microsatellite loci in 465 infections collected from 9 locations worldwide. These data reveal dramatic differences in parasite population structure in different locations. Strong linkage disequilibrium (LD) was observed in six of nine populations. Significant LD occurred in all locations with prevalence