Quality of life worsened the most severely in patients immediately after intensity-modulated radiotherapy for prostate cancer
Quality of life worsened the most severely in patients immediately after intensity-modulated radiotherapy for prostate cancer
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前列腺癌调强放疗后患者的生活质量立即恶化最严重
DOI：
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发表时间：
2018
影响因子：
1.6
通讯作者：
K. Fujimoto
中科院分区：
文献类型：
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作者：
Y. Nakai;N. Tanaka;S. Anai;M. Miyake;I. Asakawa;Y. Morizawa;S. Hori;K. Torimoto;Tomomi Fujii;M. Hasegawa;K. Fujimoto
目的本研究的目的是评估接受调强放疗（IMRT）的患者下尿路症状（LUTSs）、疾病相关生活质量（QOL）和健康相关生活质量（HR-QOL）的时间变化。患者与方法121例接受IMRT的患者，随访1 ~ 2年，采用国际前列腺症状评分（IPSS）、膀胱过度活动症状评分（OABSS）、扩展前列腺癌指数综合评分（EPIC）和8项简短健康调查（SF-8），分别在IMRT前、IMRT中点、IMRT后、IMRT完成后1 ~ 24个月进行。结果IPSS、OABSS以及EPIC的尿、肠域评分显示，患者的生活质量在IMRT中点恶化，在IMRT后立即加重，随后好转。在IMRT中点，EPIC的性域显著降低，并在24个月前显著降低。躯体功能、角色生理、身体疼痛、活力、社会功能和角色情绪领域的SF-8得分显著下降，并在IMRT后立即达到最低点。结论前列腺癌IMRT后即刻患者生活质量恶化最为严重。这些知识可以影响治疗建议，使患者能够做出更明智的决定。
Purpose The aim of this study was to evaluate the chronological changes in lower urinary tract symptoms (LUTSs), disease-related quality of life (QOL), and health-related QOL (HR-QOL) of patients who received intensity-modulated radiotherapy (IMRT). Patients and methods In 121 patients who had received IMRT and were followed up for >2 years, the International Prostate Symptom Score (IPSS), Overactive Bladder Symptom Score (OABSS), Expanded Prostate Cancer Index Composite (EPIC), and 8-Item Short-Form Health Survey (SF-8) were used before IMRT, at the halfway point in IMRT, immediately after IMRT, and 1–24 months after the completion of IMRT. Results The IPSS and OABSS and the urinary and bowel domains of the EPIC indicated that QOL worsened at the halfway point in IMRT, further worsened more severely immediately after IMRT, and then improved. The sexual domain of the EPIC significantly decreased at the halfway point in IMRT, which significantly lowered until 24 months. The scores of physical functioning, role physical, bodily pain, vitality, social functioning, and role emotional domains in the SF-8 significantly decreased and reached their lowest points immediately after IMRT. Conclusion QOL worsened the most severely in patients immediately after IMRT for prostate cancer. This knowledge can influence treatment recommendations and enable patients to make better informed decisions.
与前列腺癌患者的主动监测相比，局部冷冻疗法与全冷冻疗法以及最低肿瘤温度对患者报告的生活质量的影响。
影响因子：
2.1
作者：
Werneburg,GlennT;Kongnyuy,Michael;Halpern,DanielM;Salcedo,JoseM;Chen,Connie;LeSueur,Amanda;Kosinski,KaitlinE;Schiff,JeffreyT;Corcoran,AnthonyT;Katz,AaronE
通讯作者：
Katz,AaronE