Visual white matter integrity in schizophrenia
Visual white matter integrity in schizophrenia
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DOI：
10.1176/appi.ajp.163.11.2011
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发表时间：
2006-11-01
影响因子：
17.7
通讯作者：
Lim, Kelvin O.
中科院分区：
文献类型：
--
作者：
Butler, Pamela D.;Hoptman, Matthew J.;Lim, Kelvin O.
精神分裂症患者有视觉处理缺陷。本研究探讨视觉白色物质的完整性作为一个潜在的机制，这些defictions.Methoddiffusion张量成像被用来检查白色物质的完整性在四个层次的视觉系统中的17例精神分裂症和21个比较科目。检查的水平是视辐射，纹状皮质，顶下小叶，梭状回。ResultsSchizophrenia患者表现出显着减少，在分数各向异性的视辐射，但不是在任何其他regions.ConclusionsThis发现表明，白色物质的完整性是更受损的初始输入，而不是在更高层次的视觉系统，并支持视觉处理缺陷发生在处理早期阶段的假设。
ObjectivePatients with schizophrenia have visual-processing deficits. This study examines visual white matter integrity as a potential mechanism for these deficits.MethodDiffusion tensor imaging was used to examine white matter integrity at four levels of the visual system in 17 patients with schizophrenia and 21 comparison subjects. The levels examined were the optic radiations, the striate cortex, the inferior parietal lobule, and the fusiform gyrus.ResultsSchizophrenia patients showed a significant decrease in fractional anisotropy in the optic radiations but not in any other region.ConclusionsThis finding indicates that white matter integrity is more impaired at initial input, rather than at higher levels of the visual system, and supports the hypothesis that visual-processing deficits occur at the early stages of processing.