PROLONGED LOW-LEVEL CADMIUM INTAKE AND ATHEROSCLEROSIS
PROLONGED LOW-LEVEL CADMIUM INTAKE AND ATHEROSCLEROSIS
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DOI：
10.1016/0048-9697(93)90402-r
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发表时间：
1993-09-30
影响因子：
9.8
通讯作者：
HOUTMAN, JPW
中科院分区：
文献类型：
--
作者：
HOUTMAN, JPW
通过将荷兰镉（和锌）污染地区的住院情况与非污染地区的住院情况以及与全国的数值进行比较，分析了该地区10种疾病的发病率。对于通常与镉摄取增加有关的疾病，如肾功能不全、肾结石、高血压、癌症、新生儿不成熟等，未发现显著差异。在污染区域，只有动脉粥样硬化出现了明显更高的频率；这在40岁的男性中尤为明显。然而，没有观察到动脉粥样硬化导致更高的死亡频率。讨论了与所使用的评价技术的局限性有关的结果。污染区没有明显的重大健康风险，但长期低水平镉摄取对动脉粥样硬化可能产生的影响需要引起更多关注。
The frequencies of 10 diseases in a cadmium (and zinc) contaminated region in The Netherlands were analysed by comparing hospital admissions with those of a non-contaminated region and with national values. No significant differences were found for diseases which are commonly associated with increased cadmium uptake such as renal insufficiency, nephrolithiasis, hypertension, cancer, immaturity of the new-born. For the contaminated region a significantly higher frequency was only found for atherosclerosis; this was relatively strong for men aged >40 yrs. However, no higher death frequency for atherosclerosis was observed. The results are discussed in relation to limitations in the evaluation techniques used. The absence of major health risks in the contaminated area is obvious, but the possible influence of long term-low level cadmium uptake on atherosclerosis requires more attention.