Emerging Biological Principles of Metastasis.
Emerging Biological Principles of Metastasis.
复制标题
DOI：
10.1016/j.cell.2016.11.037
复制
发表时间：
2017-02-09
期刊：
影响因子：
64.5
通讯作者：
Weinberg RA
中科院分区：
文献类型：
--
作者：
Lambert AW;Pattabiraman DR;Weinberg RA
转移占癌症相关死亡的绝大多数，但这个复杂的过程仍然是癌症生物学中最不了解的方面。随着关于转移的研究继续以快速的速度增长，作为癌细胞扩散和转移生长基础的生物学程序开始进入人们的视野。在这篇综述中，我们总结了参与转移的细胞和分子机制，重点是已知最多的癌症，并强调转移的一般原则，已经开始出现。
Metastases account for the great majority of cancer-associated deaths, yet this complex process remains the least understood aspect of cancer biology. As the body of research concerning metastasis continues to grow at a rapid rate, the biological programs that underlie the dissemination and metastatic outgrowth of cancer cells are beginning to come into view. In this review we summarize the cellular and molecular mechanisms involved in metastasis, with a focus on carcinomas where the most is known, and highlight the general principles of metastasis that have begun to emerge.