A phosphinate-based near-infrared fluorescence probe for imaging the superoxide radical anion in vitro and in vivo
A phosphinate-based near-infrared fluorescence probe for imaging the superoxide radical anion in vitro and in vivo
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一种基于次膦酸盐的近红外荧光探针，用于体外和体内超氧自由基阴离子成像
DOI：
10.1039/c5cc09976e
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发表时间：
2016
影响因子：
4.9
通讯作者：
Zhang Haixia
中科院分区：
文献类型：
--
作者：
Zhang Jianjian;Li Chuwen;Zhang Rui;Zhang Fengyuan;Liu Wei;Liu Xiaoyan;Lee Simon Ming-Yuen;Zhang Haixia
开发了一种新的近红外（NIR），开启荧光探针CyR，其含有次膦酸酯基团作为选择性检测O2 stec −的识别部分，检测限低（LOD，9.9 nM）。CyR具有良好的细胞膜通透性、细胞内稳定性和低细胞毒性。此外，我们成功地应用CyR可视化了活斑马鱼、小鼠以及首次在小鼠肝脏中的O2 stec。
A novel near-infrared (NIR), turn-on fluorescence probe CyR containing a phosphinate group as a recognizing moiety for the selective detection of O2˙− with a low limit of detection (LOD, 9.9 nM) was developed. CyR has good cell-membrane permeability, intracellular stability, and low cytotoxicity. In addition, we successfully applied the CyR to visualize O2˙− in live zebrafish, mouse and, for the first time, in mouse liver.