A new and improved method for deglycosidation of glycopeptide antibiotics exemplified with vancomycin, ristocetin, and ramoplanin

A new and improved method for deglycosidation of glycopeptide antibiotics exemplified with vancomycin, ristocetin, and ramoplanin
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DOI:
10.1016/s0960-894x(03)00051-9
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发表时间:
2003-03-24
影响因子:
2.7
通讯作者:
Boger, DL
Boger, DL
中科院分区:
医学4区
文献类型:
--
作者:
Wanner, J;Tang, DT;Boger, DL

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A general method for the deglycosidation of glycopeptide antibiotics has been developed. Treatment of vancomycin, ristocetin, and ramoplanin with anhydrous HF results in efficient cleavage of the sugars to provide the corresponding aglycons in high yield. (C) 2003 Elsevier Science Ltd. All rights reserved.