Hippocampus, theta, and spatial memory.
Hippocampus, theta, and spatial memory.
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DOI：
10.1016/0959-4388(93)90163-s
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发表时间：
1993-12-01
影响因子：
5.7
通讯作者：
O'Keefe, J
中科院分区：
文献类型：
--
作者：
O'Keefe, J
在过去的18个月里，海马体研究的几个领域出现了有趣的发展。首先，海马theta的机制正变得越来越清楚，它在空间编码中的作用也越来越清楚;每个theta周期似乎都像一个时钟机制，位置细胞的放电可以根据这个时钟机制来计时。第二，从单个单元和损伤实验中，对海马功能的空间理论的支持不断加强;特别重要的是，在内侧颞叶损伤后的猴子中，（非空间）延迟不匹配样本记忆实验中的缺陷源于海马周围的皮质部分，而不是海马本身。第三，与此相反，证明突触水平的长时程增强与位置学习诱导的海马突触变化之间的因果关系比最初想象的要困难得多。
The past 18 months have witnessed interesting developments in several areas of hippocampal research. First, the mechanisms of hippocampal theta are becoming clear, as is its role in spatial coding; each theta cycle appears to act as a clock mechanism against which the firing of the place cells can be timed. Second, there has been a continued strengthening in the support for the spatial theory of hippocampal function from single unit and lesion experiments; particularly important is the finding that the deficit in (non-spatial) delayed non-match to sample memory experiments in the monkey following medial temporal lobe damage stems from the part of the cortex which surrounds the hippocampus, and not from the hippocampus itself. Third, in contrast, it is proving more difficult than originally thought to show a causal relationship between long-term potentiation at the synaptic level and place learning-induced changes in hippocampal synapses.