Combined glutathione S-transferase T1 and M1 positive genotypes afford protection against type 2 diabetes in Japanese
Combined glutathione S-transferase T1 and M1 positive genotypes afford protection against type 2 diabetes in Japanese
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DOI：
10.2217/14622416.8.10.1307
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发表时间：
2007-10-01
期刊：
影响因子：
2.1
通讯作者：
Nakagawa, Kazuko
中科院分区：
文献类型：
--
作者：
Hori, Masaharu;Oniki, Kentaro;Nakagawa, Kazuko
简介：糖尿病与活性氧的产生增加和抗氧化防御的减少有关。本研究的目的是确定2型糖尿病的发病率和谷胱甘肽S-转移酶（GST）基因多态性之间的关联，GST基因多态性调节氧化stress.Materials & Methods：在469名日本健康筛查项目参与者中分析2型糖尿病发病率和GSTT 1和GSTM 1基因型之间的关联。从健康筛查记录中获得临床特征和吸烟情况。GSTTI和GSTM 1缺失（-）基因型的糖尿病发病率分别是GSTT 1和GSTM 1存在（+）基因型的1.5倍。虽然每个无效基因型的影响并不显著，但与其他基因型组合相比，GSTT 1 + IGSTM 1+基因型组合可显著降低糖尿病风险（校正比值比[OR]：0.30; 95%置信区间[Cl]：0.12-0.71）。在按吸烟状态分层分析中，GSTT 1-基因型的从不吸烟者的糖尿病发病率显著高于GSTT 1+基因型者（OR：2.85; 95%CI：1.17-6.94），而当前吸烟者的糖尿病发病率显著增加（OR：5.91; 95%CI：1.96-17.88）。GSTM 1-基因型的影响是显着的，只有在目前smokers.Conclusion：这项研究表明，GSTTI-和GSTT 14 GSTMI-基因型是独立的危险因素，无论患者的吸烟状况，发展为2型糖尿病，这些基因型和目前的吸烟与2型糖尿病的发病率交互相关。
Introduction: Diabetes mellitus is associated with an increased production of reactive oxygen species and a reduction in antioxidant defenses. The aim of this study is to determine the association between the incidence of Type 2 diabetes and gene polymorphisms of glutathione S-transferase (GST), which modulates oxidative stress.Materials & Methods: The associations between the incidence of Type 2 diabetes and the GSTT1 and GSTM1 genotypes were analyzed in 469 Japanese participants in a health-screening program.Results: The clinical characteristics and smoking status were obtained from the health screening record. The incidence of diabetes was 1.5-fold higher in the GSTTI and GSTM1 null (-) genotype than the GSTT1 and GSTMI present (+) genotype, respectively. Although the effect of each null genotype was not significant, the combined GSTT1+IGSTM1+ genotypes conferred a significant reduction in risk of diabetes in comparison with the other combinations of genotypes (adjusted odds ratio [OR]: 0.30; 95% confidence interval [Cl]: 0.12-0.71). In stratified analyses by smoking status, the incidence of diabetes was significantly higher in never-smokers with the GSTT1- genotype than those with the GSTT1+ genotype (OR: 2.85; 95% CI: 1.17-6.94) and increased significantly in current smokers (OR: 5.91; 95% CI: 1.96-17.88). The effect of the GSTM1-genotype was significant only in current smokers.Conclusion: This study demonstrated that the GSTTI- and GSTT14GSTMI- genotypes are independent risk factors for development of Type 2 diabetes regardless of the smoking status of the patient, and that these genotypes and current smoking were interactively associated with the incidence of Type 2 diabetes.