Insights into the Aetiology of Ovotesticular DSD from Studies of Mouse Ovotestes
Insights into the Aetiology of Ovotesticular DSD from Studies of Mouse Ovotestes
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DOI：
10.1007/978-1-4419-8002-1_13
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发表时间：
2011-01-01
期刊：
影响因子：
--
通讯作者：
Wilhelm, Dagmar
中科院分区：
文献类型：
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作者：
Koopman, Peter;Wilhelm, Dagmar
在哺乳动物中，性别决定基因Sry(性别决定区域Y基因)是男性性别决定的主要调节基因。它诱导一系列基因表达，调节双潜能生殖器脊向睾丸组织的分化。在没有Sry的情况下，或者如果SRY功能受损，生殖器脊会发育成卵巢。随后，睾丸和卵巢产生的荷尔蒙指导所有第二性征的分化(参见Wilhelm和Koopman[1])。
In mammals,Sry(sex-determining region Y gene) is the master regulator of male sex determination. It induces a cascade of gene expression that regulates the differentiation of the bipotential genital ridges into testicular tissue. In the absence ofSry, or if SRY function is impaired, the genital ridges develop into ovaries. Subsequently, hormones produced by the testes and ovaries direct the differentiation of all secondary sexual characteristics (for review, see Wilhelm and Koopman [1]).