Estimated cochlear neural degeneration is associated with loudness hypersensitivity in individuals with normal audiograms.
Estimated cochlear neural degeneration is associated with loudness hypersensitivity in individuals with normal audiograms.
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在动物模型中，耳蜗神经变性（CND）与过度中枢增益和听觉亢进有关，但人类耳蜗神经输入减少与响度感知增强之间的令人信服的联系仍然难以捉摸。本研究调查了听力阈值正常的人类参与者中更大的耳蜗神经变性（eCND）是否与更高的响度感知和声音厌恶有关。结果表明，在有更大eCND的耳朵和通过超听问卷自述厌恶响度的受试者中，响度感知增强。这些发现表明CND可能是响度超敏症的潜在诱因。
In animal models, cochlear neural degeneration (CND) is associated with excess central gain and hyperacusis, but a compelling link between reduced cochlear neural inputs and heightened loudness perception in humans remains elusive. The present study examined whether greater estimated cochlear neural degeneration (eCND) in human participants with normal hearing thresholds is associated with heightened loudness perception and sound aversion. Results demonstrated that loudness perception was heightened in ears with greater eCND and in subjects who self-report loudness aversion via a hyperacusis questionnaire. These findings suggest that CND may be a potential trigger for loudness hypersensitivity.