Issues, indications, and controversies regarding intratympanic steroid perfusion.
Issues, indications, and controversies regarding intratympanic steroid perfusion.
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DOI：
10.1097/moo.0b013e32830ce796
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发表时间：
2008-10
影响因子：
1.6
通讯作者：
Trune D
中科院分区：
文献类型：
--
作者：
Hamid M;Trune D
Office based Intratympanic inner ear steroid perfusion treatment (ITPs) for Meniere’s disease, autoimmune inner ear disease and sudden sensorineural hearing loss has been expanding over the past 10-15 years, yet remains controversial. The purpose of this review is to examine the current literature of basic science and human studies of ITPs treatment. Animal studies exist regarding the delivery, distribution, biochemical and microbiological changes in the inner ear post ITPs. However, few clinical studies exist of ITPs treatment in sudden sensorineural hearing loss and even less in treating Meniere’s disease. There are no consistent studies regarding drug delivery methods, type and concentration of steroids. Moreover, there are no studies comparing ITPs results to the natural history of Meniere’s disease. ITPs has impacted otology and neurotology practice due to increased utilization. A sound understanding of the basic science and clinical studies is needed to establish long term efficacy of ITPs in controlling hearing loss in Meniere’s disease by comparison to its natural history, as well as, potential application to other pathologies.
