Predictive importance of galectin-3 for recurrence of non-small cell lung cancer
Predictive importance of galectin-3 for recurrence of non-small cell lung cancer
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DOI：
10.1007/s11748-019-01074-x
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发表时间：
2019-08-01
影响因子：
1.2
通讯作者：
Hanaoka, Jun
中科院分区：
文献类型：
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作者：
Kataoka, Yoko;Igarashi, Tomoyuki;Hanaoka, Jun
目的探讨半乳糖凝集素-3在非小细胞肺癌（NSCLC）中的预测作用。我们研究了半乳糖凝集素-3是否可以作为非小细胞肺癌肿瘤复发的预测因子。方法对连续42例行根治性手术的非小细胞肺癌患者，采用免疫组化方法检测肿瘤细胞中半凝集素-3的表达。术前及术后1个月采用酶联免疫吸附法测定血清半乳糖凝集素-3水平。结果半乳糖凝集素-3在肿瘤细胞中的高表达与淋巴浸润（p=0.049）和肿瘤复发（p=0.001）有显著相关性。根治性切除后无复发生存的Kaplan-Meier曲线显示，高表达半乳糖凝集素-3的患者的无复发生存期明显短于低表达半乳糖凝集素-3的患者(p
Objective The predictive importance of galectin-3 in non-small cell lung cancer (NSCLC) has not been elucidated. We examined whether galectin-3 could serve as a predictor for tumor recurrence in NSCLC.Methods In 42 consecutive patients with NSCLC who underwent radical resection, galectin-3 expression in tumor cells was examined by immunohistochemistry. Galectin-3 levels in serum were assessed before surgery and 1 month after surgery by enzyme-linked immunosorbent assays.Results Higher expression of galectin-3 in tumor cells was associated significantly with lymphatic invasion (p=0.049) and tumor recurrence (p=0.001). The Kaplan-Meier curves for relapse-free survival after radical resection showed that patients with high expression of galectin-3 had significantly shorter relapse-free survival than those with low expression of galectin-3 (p