Reversal of mineral ion homeostasis and soft-tissue calcification of klotho knockout mice by deletion of vitamin D 1alpha-hydroxylase.
Reversal of mineral ion homeostasis and soft-tissue calcification of klotho knockout mice by deletion of vitamin D 1alpha-hydroxylase.
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DOI：
10.1038/ki.2009.24
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发表时间：
2009-06
影响因子：
19.6
通讯作者：
Razzaque, M. Shawkat
中科院分区：
文献类型：
--
作者：
Ohnishi, Mutsuko;Nakatani, Teruyo;Lanske, Beate;Razzaque, M. Shawkat
Changes in the expression of klotho, a β-glucuronidase, contribute to the development of features that resemble those of premature aging, as well as chronic renal failure. Klotho knockout mice have increased expression of the sodium/phosphate cotransporter (NaPi2a) and 1α-hydroxylase in their kidneys, along with increased serum levels of phosphate and 1,25-dihydroxyvitamin D. These changes are associated with widespread soft-tissue calcifications, generalized tissue atrophy, and a shorter lifespan in the knockout mice. To determine the role of the increased vitamin D activities in klotho knockout animals, we generated klotho and 1α-hydroxylase double-knockout mice. These double mutants regained body weight and developed hypophosphatemia with a complete elimination of the soft-tissue and vascular calcifications that were routinely found in klotho knockout mice. The markedly increased serum fibroblast growth factor 23 and the abnormally low serum parathyroid hormone levels, typical of klotho knockout mice, were significantly reversed in the double-knockout animals. These in vivo studies suggest that vitamin D has a pathologic role in regulating abnormal mineral ion metabolism and soft-tissue anomalies of klotho-deficient mice.
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影响因子：
7.3
作者：
DeLuca, S.;Sitara, D.;Kang, K.;Marsell, R.;Jonsson, K.;Taguchi, T.;Erben, R. G.;Razzaque, M. S.;Lanske, B.
通讯作者：
Lanske, B.
影响因子：
4.2
作者：
Liu, Diange;Nazneen, Arifa;Razzaque, M. Shawkat
通讯作者：
Razzaque, M. Shawkat
影响因子：
6
作者：
Sitara, Despina;Razzaque, Mohammed S.;Lanske, Beate
通讯作者：
Lanske, Beate
影响因子：
4.8
作者：
Dardenne, O;Prud'homme, J;St-Arnaud, R
通讯作者：
St-Arnaud, R
影响因子：
4.2
作者：
Nabeshima, Yo-ichi;Imura, Hiroaki
通讯作者：
Imura, Hiroaki