Self-Driven Phase Transitions Drive Myxococcus xanthus Fruiting Body Formation
Self-Driven Phase Transitions Drive Myxococcus xanthus Fruiting Body Formation
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DOI：
10.1103/physrevlett.122.248102
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发表时间：
2019-06-20
影响因子：
8.6
通讯作者：
Shaevitz, Joshua W.
中科院分区：
文献类型：
--
作者：
Liu, Guannan;Patch, Adam;Shaevitz, Joshua W.
将高分辨率单细胞跟踪实验与数值模拟相结合，我们发现，黄色粘球菌中饥饿诱导的子实体形成是由细胞驱动的相分离，这些细胞随着时间的推移调整其运动性。相分离可以用细胞密度和无量纲佩克莱特数来理解，该数通过速度和反转频率捕获细胞运动。我们的工作表明，M. xanthus 利用了可以在单细胞水平上控制的自驱动非平衡相变。
Combining high-resolution single cell tracking experiments with numerical simulations, we show that starvation-induced fruiting body formation in Myxococcus xanthus is a phase separation driven by cells that tune their motility over time. The phase separation can be understood in terms of cell density and a dimensionless Peclet number that captures cell motility through speed and reversal frequency. Our work suggests that M. xanthus takes advantage of a self-driven nonequilibrium phase transition that can be controlled at the single cell level.