THE CHEMICAL COMPOSITION OF BOVINE CNS MYELIN *
THE CHEMICAL COMPOSITION OF BOVINE CNS MYELIN *
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牛中枢神经系统髓磷脂的化学成分*
DOI：
10.1111/j.1749-6632.1965.tb20193.x
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发表时间：
1965
影响因子：
5.2
通讯作者：
L. Autilio
中科院分区：
文献类型：
--
作者：
W. T. Norton;L. Autilio
多年来，人们对神经纤维髓鞘的化学成分进行了大量的推测。髓鞘成分的估计可以通过间接测量来实现，比如对快速髓鞘形成期间神经系统成分增加的灰色和白色研究的比较分析，以及对神经退化的研究。”这些估计是相当一致的，并且结合许多关于髓鞘的优秀的物理研究，给了我们目前的图像，髓鞘是细胞膜的螺旋包裹的延伸，有脂质和蛋白质的交替层，本质上是一个单位膜的浓缩系统，其中主要部分是脂质。在过去的几年中，几个研究小组已经设计出了从纯髓鞘中分离髓磷脂的方法。纯髓磷脂的fmt化学数据开始出现24-26。31日,33。用不了多久，我们就会得到大量关于纯髓磷脂组成的可靠数据。本文将讨论我们对牛脑髓磷脂的研究，并将主要集中在脂质部分的组成。
There has been considerable speculation for many years about the chemical composition of the myelin sheath of nerve fibers. Estimates of myelin composition can be made from indirect measurements, such as comparative analyses of gray and white studies of constituent increases in the nervous system during periods of rapid myelination,6-'o and studies of nerve degeneration.". l2 These estimates were fairly consistent and taken together with the many excellent physical studies on rnye l i r~ , '~-~~ give us our present picture of myelin as a helically-wrapped extension of a cell membrane, having alternate layers of lipid and protein, essentially a condensed system of unit rnernbrane~,~, the major portion of which is lipid. Within the last few years, several groups have devised procedures for the isolation of myelin in pure f ~ r m . * ~ ~ ~ The fmt chemical data on pure myelin is beginning to appear24-26. 31, 33. 3 4 and it should not be long before we have a considerable amount of reliable data on the composition of pure myelin. This paper will discuss our own work on myelin from bovine brain and will concentrate primarily on the composition of the lipid portion.