Rheumatoid arthritis complicated with acute interstitial pneumonia induced by leflunomide as an adverse reaction
Rheumatoid arthritis complicated with acute interstitial pneumonia induced by leflunomide as an adverse reaction
复制标题
DOI：
10.2169/internalmedicine.43.1201
复制
发表时间：
2004-12-01
影响因子：
1.2
通讯作者：
Minota, S
中科院分区：
文献类型：
--
作者：
Kamata, Y;Nara, H;Minota, S
一名患有类风湿关节炎的49岁日本男子在服用来氟米特17天后出现急性皮肤出疹和严重的非生产性咳嗽。由于所有细菌学检查结果均为阴性，由于胸部x线片进展迅速和动脉血氧压恶化，立即开始类固醇脉冲治疗。虽然甲氨蝶呤引起咳嗽，但在给予来氟米特之前，临床未发现间质性肺炎。在急性间质性肺炎发病128天后，他最终死于呼吸衰竭。根据上市后监测，在日本，高达1.1%的来氟米特患者发生了间质性肺炎。需要强调的是，来氟米特引起的急性间质性肺炎是一种非常严重且可能致命的副作用。
A 49-year-old Japanese man with rheumatoid arthritis acutely developed a skin eruption and severe non-productive cough seventeen days after the administration of leflunomide. Because all bacteriology findings were negative, steroid pulse-therapy was initiated promptly due to the rapidity of chest X-ray progression and the deterioration of arterial blood oxygen pressure. Although cough was induced by methotrexate, interstitial pneumonia was not detected clinically before leflunomide administration. He finally died of respiratory failure 128 days after the onset of acute interstitial pneumonia. According to the post-market surveillance, as high as similar to1.1% of the patients on leflunomide have developed interstitial pneumonia in Japan. It is important to emphasize that acute interstitial pneumonia due to leflunomide is a very severe and potentially fatal side effect.