Early endosseous integration enhanced by dual acid etching of titanium: a torque removal study in the rabbit
Early endosseous integration enhanced by dual acid etching of titanium: a torque removal study in the rabbit
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DOI：
10.1034/j.1600-0501.2001.012004350.x
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发表时间：
2001-08-01
影响因子：
4.3
通讯作者：
Nishimura, RD
中科院分区：
文献类型：
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作者：
Klokkevold, PR;Johnson, P;Nishimura, RD
纹理种植体表面被认为可以增强骨内整合。扭矩移除力已被用作锚固或骨内整合的生物力学测量，其中移除植入物所需的更大力可被解释为骨整合强度的增加。本研究的目的是比较具有双重酸蚀刻表面（Osseotite（R））的螺钉形钛种植体与具有机械加工表面或钛等离子喷涂表面（表面形貌明显更复杂）的种植体的抗扭矩移除性。本研究中使用了三种定制的螺钉形种植体类型-机加工、双重酸蚀刻（DAE）和钛等离子喷涂（TPS）。通过扫描电子显微镜和光学轮廓术对每个种植体表面进行表征。在18只成年新西兰白色家兔的每只股骨远端植入一个DAE植入物，并与其中一种植入物一起沿着。因此，每只家兔接受2个DAE植入物和1个机加工或TPS植入物。所有植入物的测量直径为3.25 mm x长度为4.00 mm，无孔、凹槽或狭槽以防止旋转。18只家兔用于反向扭矩测量。在1个月、2个月和3个月的愈合期后处死每组6只兔子。使用数字扭矩测量装置通过反向扭矩旋转取出植入物。三个种植体的机加工表面制备未能实现骨内整合。所有其他植入物均通过骨锚定。1个月、2个月和3个月时，机加工、DAE和TPS植入物的平均扭矩值分别为6.00 +/-0.64 N-cm，9.07 +/-0.67 N-cm和6.73 +/-0.95 N-cm; 21.86 +/-1.37 N-cm，27.63 +/-3.41 N-cm和27.40 +/-3.89 N-cm;分别为27.48 ± 1.61 N-cm、44.28 ± 4.53 N-cm和59.23 ± 3.88 N-cm。显然，在：在最早的时间点，DAE种植体的稳定性与TPS种植体相当，而机加工种植体的稳定性低一个数量级。TPS植入物在三个月内增加了反向扭矩移除的阻力。本研究的结果证实了我们之前的结果，即与机加工种植体相比，双酸蚀刻种植体的骨锚定增强。此外，目前的结果表明，钛的双重酸蚀刻增强了早期骨内整合到一个水平，这是由地形更复杂的TPS表面所实现的。
Textured implant surfaces are thought to enhance endosseous integration. Torque removal forces have been used as a biomechanical measure of anchorage, or endosseous integration, in which the greater forces required to remove implants may be interpreted as an increase in the strength of bony integration. The purpose of this study was to compare the torque resistance to removal of screw-shaped titanium implants having a dual acid-etched surface (Osseotite (R)) with implants having either a machined surface, or a titanium plasma spray surface that exhibited a significantly more complex surface topography. Three custom screw-shaped implant types - machined, dual acid-etched (DAE), and titanium plasma sprayed (TPS) - were used in this study. Each implant surface was characterized by scanning electron microscopy and optical profilometry. One DAE implant was placed into each distal femur of eighteen adult New Zealand White rabbits along with one of the of her implant types. Thus, each rabbit received two DAE implants and one each of the machined, or TPS, implants. All implants measured 3.25 mm in diameter x 4.00 mm in length without holes, grooves or slots to resist rotation. Eighteen rabbits were used for reverse torque measurements. Groups of six rabbits were sacrificed following one, two and three month healing periods. implants were removed by reverse torque rotation with a digital torque-measuring device. Three implants with the machined surface preparation failed to achieve endosseous integration. All other implants were anchored by bone. Mean torque values for machined, DAE and TPS implants at one, two and three months were 6.00 +/-0.64 N-cm, 9.07 +/-0.67 N-cm and 6.73 +/-0.95 N-cm; 21.86 +/-1.37 N-cm, 27.63 +/-3.41 N-cm and 27.40 +/-3.89 N-cm; and 27.48 +/-1.61 N-cm, 44.28 +/-4.53 N-cm and 59.23 +/-3.88 N-cm, respectively. Clearly, at the: earliest time point the stability of DAE implants was comparable to that of TPS implants, while that of the machined implants was an order of magnitude lower. The TPS implants increased resistance to reverse torque removal over the three-month period. The results of this study confirm our previous results that demonstrated enhanced bony anchorage to dual acid-etched implants as compared to machined implants. Furthermore, the present results indicate that dual acid etching of titanium enhances early endosseous integration to a level which is comparable to that achieved by the topographically more complex TPS surfaces.