Dietary palatinose and oleic acid ameliorate disorders of glucose and lipid metabolism in Zucker fatty rats
Dietary palatinose and oleic acid ameliorate disorders of glucose and lipid metabolism in Zucker fatty rats
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DOI：
10.1093/jn/137.8.1908
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发表时间：
2007-08-01
影响因子：
4.2
通讯作者：
Takeda, Eiji
中科院分区：
文献类型：
--
作者：
Sato, Kazusa;Arai, Hidekazu;Takeda, Eiji
过量摄入碳水化合物和脂肪与肥胖有关。然而，这些饮食因素相互作用导致代谢变化的机制尚未阐明。我们研究了不同类型的饮食碳水化合物和脂肪对Zucker脂肪（fa/fa）大鼠肥胖病因及其并发症的综合影响。具体来说，这些大鼠被喂食含有各种碳水化合物[帕丁糖(P)，一种胰岛素保留蔗糖类似物，蔗糖(S)]和脂肪酸[油酸(O)和亚油酸(L)]组合的等热量饮食。8周后，与喂食蔗糖（SO和SL）相比，喂食帕丁糖（PO和PL）导致内脏脂肪量、脂肪细胞大小、高血糖和高脂血症显著减少；饲喂腭糖也可防止胰岛肥大。与油酸喂养的大鼠（PO和SO）相比，亚油酸喂养的大鼠（PL和SL）胰岛胰岛素免疫反应染色降低，脂肪组织巨噬细胞浸润增强，血浆肿瘤坏死因子- α浓度升高。此外，蔗糖和亚油酸协同增加了参与肝脏糖异生和脂肪生成的基因[固醇调节元件结合蛋白(SREBP)-1c和SREBP-2]的表达。综上所述，含有帕丁糖和油酸的日粮可以预防饮食引起的代谢异常。帕丁糖和油酸的结合有望成为预防和治疗肥胖及其并发症的新方法。
Excessive dietary intake of carbohydrates and fats has been linked to the development of obesity. However, the mechanism by which these dietary factors interact to bring about metabolic changes has not been elucidated. We examined the combined effects of different types of dietary carbohydrates and fats on the etiology of obesity and its complications in the Zucker fatty (fa/fa) rat, a model of obesity. Specifically, these rats were fed an isocaloric diet containing various combinations of carbohydrates [palatinose (P), an insulin-sparing sucrose analogue, and sucrose (S)] and fatty acids [oleic acid (O) and linoleic acid (L)]. After 8 wk, palatinose feeding (PO and PL) led to significant reductions in visceral fat mass, adipocyte cell size, hyperglycemia, and hyperlipidemia compared with sucrose feeding (SO and SL); pancreatic islet hypertrophy was also prevented by palatinose feeding. Linoleic-acid-fed rats (PL and SL) exhibited reduced insulin-immunoreactive staining of the pancreatic islets, enhanced macrophage infiltration in adipose tissue, and an elevated plasma tumor necrosis factor-alpha concentration when compared with oleic-acid-fed rats (PO and SO). Furthermore, sucrose and linoleic acid synergistically increased the expression of genes involved in hepatic gluconeogenesis and lipogenesis [sterol regulatory-element binding protein (SREBP)-1c and SREBP-2]. In conclusion, a diet containing palatinose and oleic acid may prevent diet-induced metabolic abnormalities. The combination of palatinose and oleic acid holds promise for a new approach to preventing and treating obesity and its complications.