Histological assessment of the efficacy of drug-eluting beads in portal tumor thrombosis of hepatocellular carcinoma.
Histological assessment of the efficacy of drug-eluting beads in portal tumor thrombosis of hepatocellular carcinoma.
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DOI：
10.1016/j.radcr.2016.11.006
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发表时间：
2017-03
影响因子：
--
通讯作者：
Hiasa Y
中科院分区：
文献类型：
--
作者：
Imai Y;Hirooka M;Koizumi Y;Nakamura Y;Watanabe T;Yoshida O;Tokumoto Y;Takeshita E;Abe M;Tanaka H;Kurata M;Kitazawa S;Hiasa Y
1例58岁男性患者被诊断为晚期肝细胞癌合并门静脉癌栓。肿瘤多发，均存在于双叶。对左叶肿瘤行药物洗脱微球肝动脉化疗栓塞术(DEB-TACE)。选择胚泡和肝球作为动脉-门静脉分流管的栓塞剂，然后向左肝动脉注入负荷表阿霉素。CT显示PVTT降低。然而，肝功能衰竭继续发展，患者在DEB-TACE后67天死亡。尸检显示，珠子到达了门静脉内的肿瘤血栓。肝细胞癌合并PVTT的预后较差。虽然目前还没有针对不能切除的PVTT的既定治疗方法，但DEB-TACE可能是治疗此类病例的一个有用的选择。
A 58-year-old man was diagnosed with advanced hepatocellular carcinoma with portal vein tumor thrombosis (PVTT). The tumors were multiple and existed in both lobes. Drug-eluting beads transcatheter arterial chemoembolization (DEB-TACE) was performed for the tumors in the left lobe. Embosphere and Hepasphere were selected for embolization of the arterioportal shunt, followed by loaded epirubicin infusion into the left hepatic artery. Computed tomography showed reduction of PVTT. However, liver failure progressed, and the patient died 67 days after DEB-TACE. Autopsy showed that the beads reached the tumor thrombosis in the portal vein. The prognosis of hepatocellular carcinoma with PVTT is poor. Although there are no established treatments for unresectable PVTT, DEB-TACE might be a useful option for such cases.