Telomerase prevents the accelerated cell ageing of Werner syndrome fibroblasts
Telomerase prevents the accelerated cell ageing of Werner syndrome fibroblasts
复制标题
DOI：
10.1038/71630
复制
发表时间：
2000-01-01
期刊：
影响因子：
30.8
通讯作者：
Kipling, D
中科院分区：
文献类型：
--
作者：
Wyllie, FS;Jones, CJ;Kipling, D
Werner综合征（WS）是一种罕见的常染色体隐性遗传疾病，以加速衰老为特征。WS成纤维细胞在体外显示出加速的衰老速度2，这与这种类早衰表型有关。正常人类成纤维细胞的衰老是由端粒缩短引发的3,4,5，而WS成纤维细胞的过早衰老被认为6,7反映了DNA损伤的积累。在这里，我们表明端粒酶在WS中的强制表达可以延长细胞寿命和可能的永生。
Werner syndrome (WS) is a rare disorder inherited in an autosomal recessive manner and characterized by accelerated ageing 1. WS fibroblasts display an accelerated rate of senescence in vitro 2, which has been linked to this progeroid phenotype. The senescence of normal human fibroblasts is triggered by telomere shortening 3, 4, 5, whereas the premature senescence of WS fibroblasts has been assumed 6, 7 to reflect the accumulation of DNA damage. Here we show that forced expression of telomerase in WS confers extended cellular lifespan and probable immortality.