Feed your gut with caution!
Feed your gut with caution!
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DOI：
10.21037/tcr.2016.09.13
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发表时间：
2016-08
影响因子：
0.9
通讯作者：
Vishal K Singh;B. Yeoh;M. Vijay-Kumar
中科院分区：
文献类型：
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作者：
Vishal K Singh;B. Yeoh;M. Vijay-Kumar
肠上皮是由肠腺和绒毛组成的单层细胞，是宿主防御微生物群落及其有害代谢产物的重要组成部分。为了在持续暴露于强烈的生理和环境应激因素下保持上皮的完整性，该表面被驻留在隐窝基部的多能肠上皮干细胞持续且快速地更新。Kaiko等人最近的一项研究表明，肠隐窝的结构设计保护结肠上皮干/祖细胞免受来自肠道微生物群的增殖抑制代谢物的影响。在这些代谢产物中，丁酸盐被鉴定为结肠上皮干/祖细胞增殖的最有效的抑制剂。通过快速代谢丁酸，隐窝处的结肠细胞进一步建立代谢屏障，以保护隐窝驻留干细胞，从而为其更新和修复提供燃料。
The intestinal epithelium, a single layer of cells organized into crypts and villi, is an important component of host defense against microbial community and its noxious metabolites. To preserve the epithelium integrity under constant exposure of intense physiological and environmental stressors, this surface is continuously and rapidly renewed by pluripotent intestinal epithelial stem cells that reside in the base of crypts. A recent study by Kaiko et al. shows that structural design of intestinal crypts protects the colonic epithelial stem/progenitor cells from proliferation-suppressing metabolites derived from the gut microbiota. Among these metabolites, butyrate is identified as the most potent inhibitor of colonic epithelial stem/progenitor cells proliferation. By rapidly metabolizing the butyrate, the colonocytes at the crypt further institute a metabolic barrier to protect the crypt-resident stem cells that fuel its renewal and repair.