Chronic animal experiment with magnetically suspended centrifugal pump.
Chronic animal experiment with magnetically suspended centrifugal pump.
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磁悬浮离心泵的慢性动物实验。
DOI：
10.1111/j.1525-1594.1997.tb03713.x
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发表时间：
1997
影响因子：
2.4
通讯作者：
T. Ban
中科院分区：
文献类型：
--
作者：
T. Yamada;K. Nishimura;C. H. Park;S. Kono;S. Yuasa;T. Tsukiya;T. Akamatsu;K. Matsuda;T. Ban
我们一直在开发一种新型的长期使用的离心泵。磁悬浮离心泵(MSCP)没有轴和密封，因此可以预测较长的使用寿命。在绵羊上建立了左心房和降主动脉之间的旁心左室辅助循环。流速2.5~5.5 L/分钟。活得最长的那只羊(46天)死于泵内血栓导致的血栓。其他泵均未见血栓形成。血浆游离血红蛋白水平从9到18 mg/dl，这导致了溶血水平保持在可接受的范围内的结论。对两种驾驶模式进行了比较。恒电机电流模式下的压力-流量关系图的斜率比恒速模式下的更陡，从而减小了流量脉动。总而言之，MSCP在目前的开发阶段可以持续一个多月，是一种有前途的长期脑室辅助设备。
We have been developing a new type of centrifugal pump for long-term use. The magnetically suspended centrifugal pump (MSCP) contains no shaft and seal so that long life expectancy is predicted. Paracorporeal left ventricular (LV) assist circulation between the left atrium and the descending aorta was instituted using sheep. The flow rates ranged from 2.5-5.5 L/min. The sheep that lived the longest (46 days) died of an embolism as a result of the thrombus in the pump. No thrombus formation was observed in other pumps. Plasma free hemoglobin levels ranged from 9 to 18 mg/dl, which led to the conclusion that the hemolysis level remained within an acceptable range. Two driving modes were compared. The slope of the pressure-flow relationship plot under a constant motor current mode was steeper than that under a constant rotational speed mode, and thus, the flow fluctuation decreased. In conclusion, the MSCP is durable for more than a month at the current stage of development and is a promising device for long-term ventricular assist.
影响因子：
2.4
作者：
T. Akamatsu;T. Nakazeki;Hiroyoshi Itoh
通讯作者：
T. Akamatsu;T. Nakazeki;Hiroyoshi Itoh