A ubiquitin-like protein involved in membrane fusion.
A ubiquitin-like protein involved in membrane fusion.
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一种参与膜融合的类泛素蛋白。
DOI：
10.1016/j.cell.2007.06.041
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发表时间：
2007
期刊：
影响因子：
64.5
通讯作者：
Farré,Jean-Claude
中科院分区：
文献类型：
--
作者：
Subramani,Suresh;Farré,Jean-Claude
Atg8 是一种参与酵母自噬的类泛素蛋白，通过与脂质磷脂酰乙醇胺 (PE) 结合而靶向细胞膜。在本期《细胞》中，中门川等人。 (2007) 表明 Atg8 与 PE 缀合介导相邻膜之间的束缚并刺激膜半融合，这一事件可能模仿自噬体膜在自噬过程中的扩张。
Atg8 is a ubiquitin-like protein involved in autophagy in yeast that is targeted to membranes through conjugation to the lipid phosphatidylethanolamine (PE). In this issue ofCell, Nakatogawa et al. (2007) show that Atg8 conjugated to PE mediates tethering between adjacent membranes and stimulates membrane hemifusion, an event that may mimic expansion of the autophagosomal membrane during autophagy.