Regulation of chamber-specific gene expression in the developing heart by Irx4
Regulation of chamber-specific gene expression in the developing heart by Irx4
复制标题
DOI：
10.1126/science.283.5405.1161
复制
发表时间：
1999-02-19
期刊：
影响因子：
56.9
通讯作者：
Cepko, CL
中科院分区：
文献类型：
--
作者：
Bao, ZZ;Bruneau, BG;Cepko, CL
脊椎动物的心脏由两种类型的腔室组成，心房和心室，它们的收缩和电生理特性不同。很少有人知道的分子机制，这些腔室在胚胎发育过程中指定。在这里，一个与鸡易洛魁人相关的同源异型盒基因lrx 4被鉴定出在心脏发育的所有阶段都具有心室限制性表达模式。显示lrx 4蛋白通过激活心室肌球蛋白重链-1（VMHC 1）的表达和抑制心室中心房肌球蛋白重链-1（AMHC 1）的表达来调节肌球蛋白同种型的室特异性表达。因此，lrx 4可能在发育中的心脏中建立室特异性基因表达中起关键作用。
The vertebrate heart consists of two types of chambers, the atria and the ventricles, which differ in their contractile and electrophysiological properties. Little is known of the molecular mechanisms by which these chambers are specified during embryogenesis. Here a chicken iroquois-related homeobox gene, lrx4, was identified that has a ventricle-restricted expression pattern at all stages of heart development. lrx4 protein was shown to regulate the chamber-specific expression of myosin isoforms by activating the expression of the ventricle myosin heavy chain-1 (VMHC1) and suppressing the expression of the atrial myosin heavy chain-1 (AMHC1) in the ventricles. Thus, lrx4 may play a critical role in establishing chamber-specific gene expression in the developing heart.