Haloperidol plasma levels and clinical response: a therapeutic window relationship.
Haloperidol plasma levels and clinical response: a therapeutic window relationship.
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氟哌啶醇血浆水平和临床反应：治疗窗口关系。
DOI：
10.1176/ajp.149.4.500
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
Poland,RE
中科院分区：
文献类型：
--
作者：
VanPutten,T;Marder,SR;Mintz,J;Poland,RE
研究的目的是评估血浆氟哌啶醇和临床responsibility.Method69个新入院的药物免费精神分裂症男性之间的关系被随机分配到接受氟哌啶醇，5，10，或20毫克，每天4周，临床反应进行了测量，在固定剂量期结束。氟哌啶醇测定的灵敏度和特异性的放射免疫分析。ResultsThe作者发现固定剂量治疗期间的临床反应和血浆氟哌啶醇之间的曲线关系，与5和12 ng/ml之间的明显的最佳。当血浆水平高于12 ng/ml降至5 - 12 ng/ml范围时，所有患者均有不同程度的改善，无患者恶化。当在该治疗窗内无应答者的血浆水平升高至12 ng/ml以上时（如在常规实践中），他们总体上恶化，因为他们变得更加烦躁不安。与20毫克的剂量，一半的患者血浆水平高于12 ng/ml.ConclusionsIn新入院的精神分裂症男性，最佳的临床反应发生在血浆氟哌啶醇范围为5 - 12 ng/ml。
ObjectiveThe purpose of the study was to assess the relationship between plasma haloperidol and clinical response.MethodSixty-nine newly admitted drug-free schizophrenic men were randomly assigned to receive haloperidol, 5, 10, or 20 mg daily for 4 weeks, and clinical response was measured at the end of the fixed-dose period. Haloperidol was assayed by a sensitive and specific radioimmunoassay.ResultsThe authors found a curvilinear relationship between clinical response and plasma haloperidol during fixed-dose treatment, with an apparent optimum between 5 and 12 ng/ml. When plasma levels above 12 ng/ml were lowered to the 5-12 ng/ml range, all patients improved to varying degrees and no patient deteriorated. When plasma levels of nonresponders within this therapeutic window were raised above 12 ng/ml (as in routine practice), they, on balance, deteriorated in that they became more dysphoric. With the 20-mg dose, half the patients had plasma levels above 12 ng/ml.ConclusionsIn this sample of newly admitted schizophrenic men, optimal clinical response occurred with a plasma haloperidol range of 5-12 ng/ml.