An X-chromosome linked locus contributes to abnormal placental development in mouse interspecific hybrids
An X-chromosome linked locus contributes to abnormal placental development in mouse interspecific hybrids
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DOI：
10.1038/ng0496-398
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发表时间：
1996-04-01
期刊：
影响因子：
30.8
通讯作者：
Fundele, R
中科院分区：
文献类型：
--
作者：
Zechner, U;Reule, M;Fundele, R
亲缘关系密切的物种之间的种间杂交通常与F-1杂种的生育力或生存能力下降有关。因此，在小鼠种间杂交种中，已经描述了几种不同的杂交种不育基因，它们损害了雄性杂交种的配子发生。我们描述了一种不同种小鼠之间杂交的新效应，这种效应表现在胎盘的异常生长上。在正反交和回交中观察到相反的表型，即胎盘减少和胎盘肥大。表型的严重程度主要是由海绵状滋养层细胞的异常发育引起的，受胚胎性别的影响。一般说来，胎盘肥大与胎儿生长加快有关。胎盘营养不良常常会导致胎儿发育障碍或死亡。胎盘生长的主要遗传决定因素之一映射到小鼠X染色体的近端部分。
Interspecific hybridization between closely related species is commonly associated with decreased fertility or viability of F-1 hybrids. Thus, in mouse interspecific hybrids, several different hybrid sterility genes that impair gametogenesis of the male hybrids have been described. We describe a novel effect in hybrids between different mouse species that manifests itself in abnormal growth of the placenta. Opposite phenotypes, that is, placental hypotrophy versus hypertrophy, are observed in reciprocal crosses and backcrosses. The severity of the phenotype, which is mainly caused by abnormal development of the spongiotrophoblast, is influenced by the sex of the conceptus. In general, placental hypertrophy is associated with increased fetal growth. Hypotrophy of the placenta frequently leads to growth impairment or death of the fetus. One of the major genetic determinants of placental growth maps to the proximal part of the mouse X chromosome.