Oscillations and slow patterning in the antennal lobe.
Oscillations and slow patterning in the antennal lobe.
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触角叶中的振荡和缓慢模式。
DOI：
10.1007/s10827-006-4087-z
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发表时间：
2006
影响因子：
1.2
通讯作者：
Kopell,Nancy
中科院分区：
文献类型：
--
作者：
Sivan,Ehud;Kopell,Nancy
蝗虫、蛾和蜜蜂触角叶投射神经元的放电活动在气味呈现过程中既有快速振荡又有缓慢模式化。实验结果表明，这种振荡是AL中PN和抑制性局部神经元（LN）之间相互作用的结果;例如，通过应用GABA受体拮抗剂的阻断抑制消除了这些振荡。另一方面，缓慢的图案化被证明对这种阻塞有一定的抵抗力。在H-H模型中，我们再现了振荡和慢模式。如前所述，振荡是PN和LN之间相互作用的结果。我们认为，钙和钙依赖性钾通道（发现在PN的蜜蜂和飞蛾）是足以占缓慢的图案抗GABA受体拮抗剂的应用。PN的内在爆发属性，导致这些额外的建模电流，产生了另一个网络功能，实验中看到蝗虫：一个相对较小的增加额外产生的PN动作电位的数量时，LN输入被阻止。因此，网络抑制的主要作用是将PN的动作电位从爆发重新分配为每个振荡周期一个动作电位。
Odor presentation generates both fast oscillations and slow patterning in the spiking activity of the projection neurons (PNs) in the antennal lobe (AL) of locusts, moths and bees. Experimental results indicate that the oscillations are the result of the interaction between the PNs and the inhibitory local neurons (LNs) in the AL; e.g., blocking inhibition by application of GABA-receptor antagonists abolishes these oscillations. The slow patterning, on the other hand, was shown to be somewhat resistant to such blockage. In a H-H model, we reproduce both the oscillations and the slow patterning. As previously suggested, the oscillations are the result of the interaction between the PNs and LNs. We suggest that calcium and calcium-dependent potassium channels (found in PNs of bees and moths) are sufficient to account for the slow patterning resistant to the application of GABA-receptor antagonists. The intrinsic bursting property of the PNs, resulting from these additional modeled currents, give rise to another network feature that was seen experimentally in locusts: A relatively small increase in the number of additional generated PN action potentials when LN input is blocked. Consequently, the major effect of network inhibition is to redistribute the action potentials of the PNs from bursting to one action potential per cycle of the oscillations.