Correlation between vascular endothelial growth factor levels and prognosis of hepatocellular carcinoma patients receiving radiofrequency ablation.
Correlation between vascular endothelial growth factor levels and prognosis of hepatocellular carcinoma patients receiving radiofrequency ablation.
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DOI：
10.1080/13102818.2014.981776
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发表时间：
2015-01-02
期刊：
影响因子：
--
通讯作者：
Fan Y
中科院分区：
文献类型：
--
作者：
Guan Q;Gu J;Zhang H;Ren W;Ji W;Fan Y
本研究旨在探讨血清血管内皮生长因子（VEGF）水平对接受射频消融（RFA）的肝细胞癌（HCC）患者预后的影响。本研究纳入了110例接受CT引导下射频消融术的HCC患者。采用酶联免疫吸附法（ELISA）测定RFA前后血清VEGF水平。根据ELISA结果将患者分为阴性组和阳性组。确定患者的无进展生存时间。结果表明，血清VEGF与年龄、性别、肿瘤大小无显著相关性。肿瘤坏死周围无明显外周血供应。结果显示，与血清VEGF水平较低的患者相比，血清VEGF水平较高的患者预后较差。受试者工作特征曲线下面积与曲线下面积等于0.5时的差异有统计学意义（P < 0.05）。肝癌患者血清VEGF水平可作为评价RFA治疗效果的预后指标。
This study is aimed to investigate the effect of serum vascular endothelial growth factor (VEGF) levels on prognosis of hepatocellular carcinoma (HCC) patients receiving radiofrequency ablation (RFA). The 110 HCC patients who received computed tomography (CT) guided RFA were enrolled in this study. The levels of serum VEGF were determined before and after RFA by enzyme-linked immunosorbent assay (ELISA). According to the ELISA results, the patients were divided into the negative group and the positive group. The patient's progression-free survival time was determined. It was demonstrated that the serum VEGF had no significant correlation with ages, sex and tumour size. There were no significant peripheral blood supplies around tumour necrosis. The results showed that higher levels of serum VEGF had a worse prognosis when compared to the patients with lower levels of serum VEGF. The difference between the area under the receiver operating characteristic curve and those when area under curves equalled 0.5 was statistically significant (P < 0.05). The serum VEGF level in liver cancer patients can be used as a prognostic indicator for evaluating the efficacy of RFA treatments.
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影响因子：
9
作者：
Nijkamp, Maarten W.;van der Bilt, Jarmila D. W.;Rinkes, Inne H. M. Borel
通讯作者：
Rinkes, Inne H. M. Borel
影响因子：
25.7
作者：
Nijkamp, Maarten W.;Hoogwater, Frederik J. H.;Kranenburg, Onno
通讯作者：
Kranenburg, Onno
影响因子：
9.8
作者：
Sergio, Adriana;Cristofori, Chiara;Farinati, Fabio
通讯作者：
Farinati, Fabio
影响因子：
11.2
作者：
Liu, YQ;Poon, RT;Fan, ST
通讯作者：
Fan, ST
影响因子：
3.1
作者：
Hendriksen, E. M.;Span, P. N.;Bussink, J.
通讯作者：
Bussink, J.